ID   MSMF_STRMU              Reviewed;         290 AA.
AC   Q00750;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2002, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Multiple sugar-binding transport system permease protein MsmF;
GN   Name=msmF; OrderedLocusNames=SMU_879;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ingbritt;
RX   PubMed=1537846; DOI=10.1016/s0021-9258(18)42880-3;
RA   Russell R.R.B., Aduse-Opoku J., Sutcliffe I.C., Tao L., Ferretti J.J.;
RT   "A binding protein-dependent transport system in Streptococcus mutans
RT   responsible for multiple sugar metabolism.";
RL   J. Biol. Chem. 267:4631-4637(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Involved in a binding protein-dependent transport system
CC       responsible for the uptake of melibiose, raffinose and isomaltotriose.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. MalFG subfamily. {ECO:0000305}.
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DR   EMBL; M77351; AAA26935.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN58594.1; -; Genomic_DNA.
DR   PIR; C42400; C42400.
DR   RefSeq; NP_721288.1; NC_004350.2.
DR   RefSeq; WP_002262873.1; NC_004350.2.
DR   AlphaFoldDB; Q00750; -.
DR   SMR; Q00750; -.
DR   STRING; 210007.SMU_879; -.
DR   TCDB; 3.A.1.1.28; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAN58594; AAN58594; SMU_879.
DR   GeneID; 66817685; -.
DR   KEGG; smu:SMU_879; -.
DR   PATRIC; fig|210007.7.peg.785; -.
DR   eggNOG; COG1175; Bacteria.
DR   HOGENOM; CLU_016047_0_0_9; -.
DR   OMA; WLAYPFM; -.
DR   PhylomeDB; Q00750; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..290
FT                   /note="Multiple sugar-binding transport system permease
FT                   protein MsmF"
FT                   /id="PRO_0000060117"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        231..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          70..281
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   CONFLICT        40
FT                   /note="T -> I (in Ref. 1; AAA26935)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        76
FT                   /note="L -> S (in Ref. 1; AAA26935)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   290 AA;  31917 MW;  7EF61595A899E7FD CRC64;
     MTIRKVLNKY WGWTFLIVPL ILQVVFFYFP MFQGAFYSFT NWTGLTYNFD FVGINNYKIL
     MTDGKFMKAI GFTLVLTLAL IVGEIVLGII IARALNAKIK GKTFFRAWFF FPAVLSGLTV
     SLIFKQVFNY GLPAVGSALG IKFLETSMLG TANGAVIASI FVLLWQGVAM PIILFLSGLQ
     SIPSEIVEAA AIDGADSKQT FWSVELPYLL PSISMVFIMA LKAGLTAFDQ IFALTGGGPN
     NSTTSLGLLV YNYAFKSNQY GYANAIALIL FIIIGIVSVL QIKLSKKFEV