ID   MSMG_STRMU              Reviewed;         277 AA.
AC   Q00751;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Multiple sugar-binding transport system permease protein MsmG;
GN   Name=msmG; OrderedLocusNames=SMU_880;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ingbritt;
RX   PubMed=1537846; DOI=10.1016/s0021-9258(18)42880-3;
RA   Russell R.R.B., Aduse-Opoku J., Sutcliffe I.C., Tao L., Ferretti J.J.;
RT   "A binding protein-dependent transport system in Streptococcus mutans
RT   responsible for multiple sugar metabolism.";
RL   J. Biol. Chem. 267:4631-4637(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Involved in a binding protein-dependent transport system
CC       responsible for the uptake of melibiose, raffinose and isomaltotriose.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. MalFG subfamily. {ECO:0000305}.
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DR   EMBL; M77351; AAA26936.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN58595.1; -; Genomic_DNA.
DR   PIR; B27626; B27626.
DR   PIR; D42400; D42400.
DR   RefSeq; NP_721289.1; NC_004350.2.
DR   RefSeq; WP_002262874.1; NC_004350.2.
DR   AlphaFoldDB; Q00751; -.
DR   SMR; Q00751; -.
DR   STRING; 210007.SMU_880; -.
DR   TCDB; 3.A.1.1.28; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAN58595; AAN58595; SMU_880.
DR   GeneID; 66817684; -.
DR   KEGG; smu:SMU_880; -.
DR   PATRIC; fig|210007.7.peg.786; -.
DR   eggNOG; COG0395; Bacteria.
DR   HOGENOM; CLU_016047_1_2_9; -.
DR   OMA; YIVFQRQ; -.
DR   PhylomeDB; Q00751; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..277
FT                   /note="Multiple sugar-binding transport system permease
FT                   protein MsmG"
FT                   /id="PRO_0000060118"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          69..263
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   277 AA;  31654 MW;  C6B6D5C2F805B61A CRC64;
     MKKEEKINYF WKYVLLTVGG ILILIPLMVT VFSSFKKTKD IMNHFFAFPN PITLDNYKRL
     LADGVGGYFW NSTVITVLSV LVVMLFIPAA AYSIARNMSR RKAFNIMYSL LILGIFVPFQ
     VIMIPITVMM SKLGLANMWG LIILYLTYAI PQTLFLYVGY IKLSVPDSLD EAAEIDGADK
     LTTYRKIIFP MLKPMHATTL IINALWFWND FMLPLLILNK DSSMWTLPLF QYNYSGQYFN
     DYGPSFASYI VGIITITIVY LIFQKHIIAG MSNGAVK