ID   MSMK_STRMU              Reviewed;         377 AA.
AC   Q00752;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Multiple sugar-binding transport ATP-binding protein MsmK;
GN   Name=msmK; OrderedLocusNames=SMU_882;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Ingbritt;
RX   PubMed=1537846; DOI=10.1016/s0021-9258(18)42880-3;
RA   Russell R.R.B., Aduse-Opoku J., Sutcliffe I.C., Tao L., Ferretti J.J.;
RT   "A binding protein-dependent transport system in Streptococcus mutans
RT   responsible for multiple sugar metabolism.";
RL   J. Biol. Chem. 267:4631-4637(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Involved in a binding protein-dependent transport system
CC       responsible for the uptake of melibiose, raffinose and isomaltotriose.
CC       Probably responsible for energy coupling to the transport system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR   EMBL; M77351; AAA26938.1; -; Genomic_DNA.
DR   EMBL; AE014133; AAN58597.1; -; Genomic_DNA.
DR   PIR; E42400; E42400.
DR   RefSeq; NP_721291.1; NC_004350.2.
DR   RefSeq; WP_002262876.1; NC_004350.2.
DR   AlphaFoldDB; Q00752; -.
DR   SMR; Q00752; -.
DR   STRING; 210007.SMU_882; -.
DR   TCDB; 3.A.1.1.28; the atp-binding cassette (abc) superfamily.
DR   PRIDE; Q00752; -.
DR   EnsemblBacteria; AAN58597; AAN58597; SMU_882.
DR   KEGG; smu:SMU_882; -.
DR   PATRIC; fig|210007.7.peg.788; -.
DR   eggNOG; COG3842; Bacteria.
DR   HOGENOM; CLU_000604_1_1_9; -.
DR   OMA; PRNMYDK; -.
DR   PhylomeDB; Q00752; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   CDD; cd03301; ABC_MalK_N; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR015855; ABC_transpr_MalK-like.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR040582; OB_MalK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005116; Transp-assoc_OB_typ1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF17912; OB_MalK; 1.
DR   Pfam; PF03459; TOBE; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW   Reference proteome; Sugar transport; Transport.
FT   CHAIN           1..377
FT                   /note="Multiple sugar-binding transport ATP-binding protein
FT                   MsmK"
FT                   /id="PRO_0000092612"
FT   DOMAIN          4..246
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   377 AA;  41964 MW;  640FAD092289736A CRC64;
     MVELNLNHIY KKYPNSSHYS VEDFDLDIKN KEFIVFVGPS GCGKSTTLRM VAGLEDITKG
     ELKIDGEVVN DKAPKDRDIA MVFQNYALYP HMSVYDNMAF GLKLRHYSKE AIDKRVKEAA
     QILGLTEFLE RKPADLSGGQ RQRVAMGRAI VRDAKVFLMD EPLSNLDAKL RVSMRAEIAK
     IHRRIGATTI YVTHDQTEAM TLADRIVIMS STKNEDGSGT IGRVEQVGTP QELYNRPANK
     FVAGFIGSPA MNFFDVTIKD GHLVSKDGLT IAVTEGQLKM LESKGFKNKN LIFGIRPEDI
     SSSLLVQETY PDATVDAEVV VSELLGSETM LYLKLGQTEF AARVDARDFH EPGEKVSLTF
     NVAKGHFFDA ETEAAIR