ID   MSMP_MOUSE              Reviewed;         139 AA.
AC   B1AWI6;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Prostate-associated microseminoprotein;
DE   AltName: Full=PC3-secreted microprotein homolog;
DE   Flags: Precursor;
GN   Name=Msmp; Synonyms=Psmp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (By
CC       similarity). Signals through binding and activation of CCR2 and induces
CC       a strong chemotactic response and mobilization of intracellular calcium
CC       ions (By similarity). Exhibits a chemotactic activity for monocytes and
CC       lymphocytes but not neutrophils (By similarity).
CC       {ECO:0000250|UniProtKB:Q1L6U9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q1L6U9}.
CC   -!- SIMILARITY: Belongs to the beta-microseminoprotein family.
CC       {ECO:0000305}.
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DR   EMBL; AL732626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS51167.1; -.
DR   RefSeq; NP_001092784.1; NM_001099314.1.
DR   AlphaFoldDB; B1AWI6; -.
DR   SMR; B1AWI6; -.
DR   STRING; 10090.ENSMUSP00000103516; -.
DR   PhosphoSitePlus; B1AWI6; -.
DR   PaxDb; B1AWI6; -.
DR   PRIDE; B1AWI6; -.
DR   Antibodypedia; 56375; 12 antibodies from 7 providers.
DR   Ensembl; ENSMUST00000107884; ENSMUSP00000103516; ENSMUSG00000078719.
DR   GeneID; 100039672; -.
DR   KEGG; mmu:100039672; -.
DR   UCSC; uc008sql.1; mouse.
DR   CTD; 692094; -.
DR   MGI; MGI:3652339; Msmp.
DR   VEuPathDB; HostDB:ENSMUSG00000078719; -.
DR   eggNOG; ENOG502SBBR; Eukaryota.
DR   GeneTree; ENSGT00940000154371; -.
DR   HOGENOM; CLU_153313_0_0_1; -.
DR   InParanoid; B1AWI6; -.
DR   OMA; DLEWGSA; -.
DR   OrthoDB; 1429039at2759; -.
DR   PhylomeDB; B1AWI6; -.
DR   TreeFam; TF338336; -.
DR   BioGRID-ORCS; 100039672; 1 hit in 39 CRISPR screens.
DR   PRO; PR:B1AWI6; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; B1AWI6; protein.
DR   Bgee; ENSMUSG00000078719; Expressed in embryonic post-anal tail and 41 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0031727; F:CCR2 chemokine receptor binding; ISS:UniProtKB.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:0002548; P:monocyte chemotaxis; ISS:UniProtKB.
DR   InterPro; IPR008735; PSP94.
DR   PANTHER; PTHR10500; PTHR10500; 1.
DR   Pfam; PF05825; PSP94; 1.
PE   3: Inferred from homology;
KW   Chemotaxis; Cytokine; Disulfide bond; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   CHAIN           36..139
FT                   /note="Prostate-associated microseminoprotein"
FT                   /id="PRO_0000338649"
FT   REGION          116..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        38..78
FT                   /evidence="ECO:0000250|UniProtKB:P08118"
FT   DISULFID        46..69
FT                   /evidence="ECO:0000250|UniProtKB:P08118"
FT   DISULFID        64..100
FT                   /evidence="ECO:0000250|UniProtKB:P08118"
FT   DISULFID        67..77
FT                   /evidence="ECO:0000250|UniProtKB:P08118"
FT   DISULFID        91..114
FT                   /evidence="ECO:0000250|UniProtKB:P08118"
SQ   SEQUENCE   139 AA;  14981 MW;  EBF8B9716C190B2C CRC64;
     MALRMLWAGQ AKGILGGWRT ICLVVSLFLQ HPGVSSKCYF QAQAPCHYEG KYFTLGESWL
     RKDCFHCTCL HPVGVGCCDT AQHPIDFPAE CEVLQEAGTC QFSLVQKADP RLPCKGGGPD
     LEWGSANTPA PGASAPHSS