MSP19_CAEEL
ID MSP19_CAEEL Reviewed; 127 AA.
AC P53017;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142;
DE Short=MSP;
GN Name=msp-19; ORFNames=F36H12.7;
GN and
GN Name=msp-31; ORFNames=R05F9.13;
GN and
GN Name=msp-40; ORFNames=C33F10.9;
GN and
GN Name=msp-45; ORFNames=F58A6.8;
GN and
GN Name=msp-50; ORFNames=C34F11.4;
GN and
GN Name=msp-51; ORFNames=ZK354.5;
GN and
GN Name=msp-53; ORFNames=R13H9.4;
GN and
GN Name=msp-59; ORFNames=ZK354.11;
GN and
GN Name=msp-64; ORFNames=ZK1248.6;
GN and
GN Name=msp-65; ORFNames=ZK354.1;
GN and
GN Name=msp-81; ORFNames=K07F5.1;
GN and
GN Name=msp-113; ORFNames=ZK354.4;
GN and
GN Name=msp-142; ORFNames=K05F1.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS), AND SUBUNIT.
RX PubMed=12051923; DOI=10.1016/s0022-2836(02)00294-2;
RA Baker A.M., Roberts T.M., Stewart M.;
RT "2.6 A resolution crystal structure of helices of the motile major sperm
RT protein (MSP) of Caenorhabditis elegans.";
RL J. Mol. Biol. 319:491-499(2002).
CC -!- FUNCTION: Central component in molecular interactions underlying sperm
CC crawling. Forms an extensive filament system that extends from sperm
CC villipoda, along the leading edge of the pseudopod.
CC -!- SUBUNIT: Helical subfilaments are built from MSP dimers; filaments are
CC formed from two subfilaments coiling round one another; and filaments
CC themselves supercoil to produce bundles. {ECO:0000269|PubMed:12051923}.
CC -!- SUBCELLULAR LOCATION: Cell projection, pseudopodium. Cytoplasm,
CC cytoskeleton.
CC -!- TISSUE SPECIFICITY: Sperm.
CC -!- MISCELLANEOUS: Around 30 MSP isoforms may exist in C.elegans.
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DR EMBL; FO080275; CCD62525.1; -; Genomic_DNA.
DR EMBL; FO080689; CCD65824.1; -; Genomic_DNA.
DR EMBL; FO080690; CCD65838.1; -; Genomic_DNA.
DR EMBL; FO080763; CCD66514.1; -; Genomic_DNA.
DR EMBL; FO081106; CCD69142.1; -; Genomic_DNA.
DR EMBL; FO081120; CCD69279.1; -; Genomic_DNA.
DR EMBL; FO081309; CCD70664.1; -; Genomic_DNA.
DR EMBL; FO081310; CCD70677.1; -; Genomic_DNA.
DR EMBL; FO081310; CCD70681.1; -; Genomic_DNA.
DR EMBL; FO081310; CCD70682.1; -; Genomic_DNA.
DR EMBL; FO081310; CCD70687.1; -; Genomic_DNA.
DR EMBL; FO081574; CCD72508.1; -; Genomic_DNA.
DR PIR; A88165; A88165.
DR PIR; B88689; B88689.
DR PIR; C88688; C88688.
DR PIR; C88689; C88689.
DR PIR; D88164; D88164.
DR PIR; E88134; E88134.
DR PIR; F88138; F88138.
DR PIR; G88145; G88145.
DR PIR; G88686; G88686.
DR PIR; H88146; H88146.
DR PIR; H88688; H88688.
DR PIR; H88792; H88792.
DR RefSeq; NP_494865.1; NM_062464.6.
DR RefSeq; NP_494898.1; NM_062497.6.
DR RefSeq; NP_494959.1; NM_062558.8.
DR RefSeq; NP_494972.1; NM_062571.8.
DR RefSeq; NP_495144.1; NM_062743.4.
DR RefSeq; NP_495149.1; NM_062748.3.
DR RefSeq; NP_500714.1; NM_068313.5.
DR RefSeq; NP_500760.1; NM_068359.5.
DR RefSeq; NP_500771.1; NM_068370.7.
DR RefSeq; NP_500773.1; NM_068372.6.
DR RefSeq; NP_500778.1; NM_068377.7.
DR RefSeq; NP_500780.1; NM_068379.4.
DR RefSeq; NP_501759.1; NM_069358.4.
DR PDB; 1GRW; X-ray; 2.60 A; A/B/C/D=2-127.
DR PDBsum; 1GRW; -.
DR AlphaFoldDB; P53017; -.
DR SMR; P53017; -.
DR BioGRID; 39184; 1.
DR BioGRID; 39234; 1.
DR BioGRID; 39322; 2.
DR BioGRID; 39324; 1.
DR BioGRID; 42931; 1.
DR BioGRID; 56828; 1.
DR DIP; DIP-25397N; -.
DR IntAct; P53017; 1.
DR STRING; 6239.C33F10.9; -.
DR EPD; P53017; -.
DR PaxDb; P53017; -.
DR PeptideAtlas; P53017; -.
DR EnsemblMetazoa; C33F10.9.1; C33F10.9.1; WBGene00003435.
DR EnsemblMetazoa; C34F11.4.1; C34F11.4.1; WBGene00003443.
DR EnsemblMetazoa; F36H12.7.1; F36H12.7.1; WBGene00003426.
DR EnsemblMetazoa; F58A6.8.1; F58A6.8.1; WBGene00003438.
DR EnsemblMetazoa; K05F1.2.1; K05F1.2.1; WBGene00003469.
DR EnsemblMetazoa; R05F9.13.1; R05F9.13.1; WBGene00003429.
DR EnsemblMetazoa; R13H9.4.1; R13H9.4.1; WBGene00003446.
DR EnsemblMetazoa; ZK1248.6.1; ZK1248.6.1; WBGene00003457.
DR EnsemblMetazoa; ZK354.1.1; ZK354.1.1; WBGene00003458.
DR EnsemblMetazoa; ZK354.11.1; ZK354.11.1; WBGene00003452.
DR EnsemblMetazoa; ZK354.4.1; ZK354.4.1; WBGene00003468.
DR EnsemblMetazoa; ZK354.5.1; ZK354.5.1; WBGene00003444.
DR GeneID; 173830; -.
DR GeneID; 173849; -.
DR GeneID; 173884; -.
DR GeneID; 173890; -.
DR GeneID; 173981; -.
DR GeneID; 173983; -.
DR GeneID; 177275; -.
DR GeneID; 177309; -.
DR GeneID; 177311; -.
DR GeneID; 191292; -.
DR GeneID; 259801; -.
DR KEGG; cel:CELE_C33F10.9; -.
DR KEGG; cel:CELE_C34F11.4; -.
DR KEGG; cel:CELE_F58A6.8; -.
DR KEGG; cel:CELE_K05F1.2; -.
DR KEGG; cel:CELE_R05F9.13; -.
DR KEGG; cel:CELE_R13H9.4; -.
DR KEGG; cel:CELE_ZK1248.6; -.
DR KEGG; cel:CELE_ZK354.1; -.
DR KEGG; cel:CELE_ZK354.11; -.
DR KEGG; cel:CELE_ZK354.4; -.
DR KEGG; cel:CELE_ZK354.5; -.
DR UCSC; C33F10.9; c. elegans.
DR CTD; 173830; -.
DR CTD; 173849; -.
DR CTD; 173884; -.
DR CTD; 173890; -.
DR CTD; 173981; -.
DR CTD; 173983; -.
DR CTD; 177275; -.
DR CTD; 177309; -.
DR CTD; 177311; -.
DR CTD; 191292; -.
DR CTD; 259801; -.
DR WormBase; C33F10.9; CE02806; WBGene00003435; msp-40.
DR WormBase; C34F11.4; CE02806; WBGene00003443; msp-50.
DR WormBase; F36H12.7; CE02806; WBGene00003426; msp-19.
DR WormBase; F58A6.8; CE02806; WBGene00003438; msp-45.
DR WormBase; K05F1.2; CE02806; WBGene00003469; msp-142.
DR WormBase; K07F5.1; CE02806; WBGene00003467; msp-81.
DR WormBase; R05F9.13; CE02806; WBGene00003429; msp-31.
DR WormBase; R13H9.4; CE02806; WBGene00003446; msp-53.
DR WormBase; ZK1248.6; CE02806; WBGene00003457; msp-64.
DR WormBase; ZK354.1; CE02806; WBGene00003458; msp-65.
DR WormBase; ZK354.11; CE02806; WBGene00003452; msp-59.
DR WormBase; ZK354.4; CE02806; WBGene00003468; msp-113.
DR WormBase; ZK354.5; CE02806; WBGene00003444; msp-51.
DR eggNOG; ENOG502RXF6; Eukaryota.
DR GeneTree; ENSGT00970000195833; -.
DR HOGENOM; CLU_120664_0_1_1; -.
DR InParanoid; P53017; -.
DR OrthoDB; 1405423at2759; -.
DR PhylomeDB; P53017; -.
DR EvolutionaryTrace; P53017; -.
DR PRO; PR:P53017; -.
DR Proteomes; UP000001940; Chromosome II.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003426; Expressed in adult organism and 2 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR Pfam; PF00635; Motile_Sperm; 1.
DR SUPFAM; SSF49354; SSF49354; 1.
DR PROSITE; PS50202; MSP; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cell projection; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..127
FT /note="Major sperm protein
FT 19/31/40/45/50/51/53/59/61/65/81/113/142"
FT /id="PRO_0000213437"
FT DOMAIN 9..126
FT /note="MSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250"
FT STRAND 10..16
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 18..22
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 28..36
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 38..40
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 42..49
FT /evidence="ECO:0007829|PDB:1GRW"
FT TURN 51..53
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 54..63
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 68..75
FT /evidence="ECO:0007829|PDB:1GRW"
FT HELIX 80..82
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 89..96
FT /evidence="ECO:0007829|PDB:1GRW"
FT HELIX 107..110
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 112..114
FT /evidence="ECO:0007829|PDB:1GRW"
FT STRAND 117..126
FT /evidence="ECO:0007829|PDB:1GRW"
SQ SEQUENCE 127 AA; 14209 MW; 69F69631BEA5B147 CRC64;
MAQSVPPGDI QTQPGTKIVF NAPYDDKHTY HIKVINSSAR RIGYGIKTTN MKRLGVDPPC
GVLDPKEAVL LAVSCDAFAF GQEDTNNDRI TVEWTNTPDG AAKQFRREWF QGDGMVRRKN
LPIEYNP
