ID   MSP1_CAEEL              Reviewed;         342 AA.
AC   P54815; Q95ZR8;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2002, sequence version 2.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Mitochondrial sorting homolog;
GN   Name=mspn-1; ORFNames=K04D7.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Involved in intramitochondrial sorting of proteins.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a;
CC         IsoId=P54815-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=P54815-2; Sequence=VSP_000023;
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; Z69664; CAA93516.2; -; Genomic_DNA.
DR   EMBL; Z69664; CAC42312.1; -; Genomic_DNA.
DR   PIR; T23311; T23311.
DR   RefSeq; NP_501860.1; NM_069459.6. [P54815-1]
DR   RefSeq; NP_501861.1; NM_069460.1. [P54815-2]
DR   AlphaFoldDB; P54815; -.
DR   SMR; P54815; -.
DR   BioGRID; 42998; 1.
DR   IntAct; P54815; 1.
DR   STRING; 6239.K04D7.2a; -.
DR   EPD; P54815; -.
DR   PaxDb; P54815; -.
DR   PeptideAtlas; P54815; -.
DR   EnsemblMetazoa; K04D7.2a.1; K04D7.2a.1; WBGene00010557. [P54815-1]
DR   EnsemblMetazoa; K04D7.2b.1; K04D7.2b.1; WBGene00010557. [P54815-2]
DR   GeneID; 177896; -.
DR   KEGG; cel:CELE_K04D7.2; -.
DR   UCSC; K04D7.2a; c. elegans. [P54815-1]
DR   CTD; 177896; -.
DR   WormBase; K04D7.2a; CE28240; WBGene00010557; mspn-1. [P54815-1]
DR   WormBase; K04D7.2b; CE28241; WBGene00010557; mspn-1. [P54815-2]
DR   eggNOG; KOG0737; Eukaryota.
DR   GeneTree; ENSGT00940000166329; -.
DR   InParanoid; P54815; -.
DR   OMA; CKQAAFI; -.
DR   OrthoDB; 1430018at2759; -.
DR   PhylomeDB; P54815; -.
DR   Reactome; R-CEL-9603798; Class I peroxisomal membrane protein import.
DR   SignaLink; P54815; -.
DR   PRO; PR:P54815; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00010557; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140570; P:extraction of mislocalized protein from mitochondrial outer membrane; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; ATP-binding; Membrane; Mitochondrion;
KW   Mitochondrion outer membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..342
FT                   /note="Mitochondrial sorting homolog"
FT                   /id="PRO_0000084758"
FT   TOPO_DOM        1..6
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        26..342
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   BINDING         124..131
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         46..48
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_000023"
SQ   SEQUENCE   342 AA;  37662 MW;  D4CB88E3EC5CEE3F CRC64;
     MTDRNELIGV AIRVVAAAAV SFLSVRYLVK YLDPNYSVNE ESKKKVAQLF HELGIDRQIE
     LSEHEIRIAT QFVGGEDVGA DWDEIGGCEE LVAELKDRII LPLRFASQSG SHLLSPPRGI
     LLYGPPGCGK TLLAKAVARA AGCRFINLQV SNLTDKWYGE SQKLAAAVFS VAQKFQPTII
     FIDEIDSFLR DRQSHDHEST AMMKAQFMTL WDGFSSSGDQ IIVMGATNRP RDVDAAILRR
     MTARFQVPVP NAKQRSQILN VILRNEKINN TVNLGEIAQA AEGLSGSDLK EVCRLALLAR
     AKATVASGGS VNQLLPLEQS DFESAVHKYM RAAHLLVEET LD