MSP1_PLAF3
ID MSP1_PLAF3 Reviewed; 1682 AA.
AC P19598; Q25921;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Merozoite surface protein 1;
DE AltName: Full=Merozoite surface antigens;
DE AltName: Full=PMMSA;
DE AltName: Full=p190;
DE Flags: Precursor;
GN Name=MSP-1;
OS Plasmodium falciparum (isolate ro-33 / Ghana).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5834;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-1061.
RX PubMed=3327688; DOI=10.1002/j.1460-2075.1987.tb02759.x;
RA Certa U., Rotmann D., Matile H., Reber-Liske R.;
RT "A naturally occurring gene encoding the major surface antigen precursor
RT p190 of Plasmodium falciparum lacks tripeptide repeats.";
RL EMBO J. 6:4137-4142(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1032-1682.
RX PubMed=7628566; DOI=10.1006/expr.1995.1091;
RA Tolle R., Bujard H., Cooper J.A.;
RT "Plasmodium falciparum: variations within the C-terminal region of
RT merozoite surface antigen-1.";
RL Exp. Parasitol. 81:47-54(1995).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- PTM: Merozoite surface antigen contain the sequence of 83 kDa, 42 kDa
CC and 19 kDa antigens which are the major surface antigens of merozoites.
CC The maturation take place during schizont.
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DR EMBL; M35727; AAA29715.1; -; mRNA.
DR EMBL; Y00087; CAA68280.1; -; Genomic_DNA.
DR EMBL; Z35326; CAA84555.1; -; Genomic_DNA.
DR AlphaFoldDB; P19598; -.
DR BMRB; P19598; -.
DR SMR; P19598; -.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Malaria; Membrane; Merozoite; Repeat; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..1661
FT /note="Merozoite surface protein 1"
FT /id="PRO_0000024552"
FT PROPEP 1662..1682
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000024553"
FT REGION 68..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1212..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1433..1453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..715
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..914
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1221..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 1661
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000250"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 462
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 599
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 785
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 881
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 901
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 947
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1071
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1178
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1569
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 1575..1586
FT /evidence="ECO:0000250"
FT DISULFID 1580..1596
FT /evidence="ECO:0000250"
FT DISULFID 1598..1609
FT /evidence="ECO:0000250"
FT DISULFID 1617..1630
FT /evidence="ECO:0000250"
FT DISULFID 1624..1644
FT /evidence="ECO:0000250"
FT DISULFID 1646..1660
FT /evidence="ECO:0000250"
SQ SEQUENCE 1682 AA; 192463 MW; C82A1E159948CAD6 CRC64;
MKIIFFLCSF LFFIINTQCV THESYQELVK KLEALEDAVL TGYSLFQKEK MVLKDGANTQ
VVAKPADAVS TQSAKNPPGA TVPSGTASTK GAIRSPGAAN PSDDSSDSDA KSYADLKHRV
QNYLFTIKEL KYPELFDLTN HMLTLCDNIH GFKYLIDGYE EINELLYKLN FYFDLLRAKL
NDVCANDYCQ IPFNLKIRAN ELDVLKKLVF GYRKPLDFIK DNVGKMEDYI KKNKTTIANI
NELIEGSKKT IDQNKNADNE EGKKKLYQAQ YDLFIYNKQL QEAHNLISVL EKRIDTLKKN
ENIKKLLEDI DKIKIDAEKP TTGVNQILSL RLEKESRHEE KIKEIAKTIK FNIDRLFTDP
LELEYYLREK NKKVDVTPKS QDPTKSVQIP KVPYPNGIVY PLPLTDIHNS LAADNDKNSY
GDLMNPHTKE KINEKIITDN KERKIFINNI KKQIDLEEKN INHTKEQNKK LLEDYEKSKK
DYEELLEKFY EMKFNNNFNK DVVDKIFSAR YTYNVEKQRY NNKFSSSNNS VYNVQKLKKA
LSYLEDYSLR KGISEKDFNH YYTLKTGLEA DIKKLTEEIK SSENKILEKN FKGLTHSANA
SLEVSDIVKL QVQKVLLIKK IEDLRKIELF LKNAQLKDSI HVPNIYKPQN KPEPYYLIVL
KKEVDKLKEF IPKVKDMLKK EQAVLSSITQ PLVAASETTE DGGHSTHTLS QSGETEVTEE
TEETVGHTTT VTITLPPKEV KVVENSIEHK SNDNSQALTK TVYLKKLDEF LTKSYICHKY
ILVSNSSMDQ KLLEVYNLTP EENELKSCDR LDLLFNIQNN IPAMYSLYDS MNNDLQHLFF
ELYQKEMIYY LHKLKEENHI KKLLEEPKQI TGTSSTSSPG NTTVNTAQSA THSNSQNQQS
NASSTNTQNG VAVSSGPAVV EESHDPLTVL SISNDLKGIV SLLNLGNKTK VPNPLTISTT
EMEKFYENIL KIMIPIFNDD IKQFVKSNSK VITGLTETQK NALNDEIKKL KDTLQLSFDL
YNKYKLKLDR LFNKKKELGQ DKMQIKKLTL LKEQLESKLN SLNNPHNVLQ NFSVFFNKKK
EAEIAETENT LENTKILLKH YKGLVKYYNG ESSPLKTLSE VSIQTEDNYA NLEKFRVLSK
IDGKLNDNLH LGKKKLSFLS SGLHHLITEL KEVIKNKNYT GNSPSENNKK VNEALKSYEN
FLPEAKVTTV VTPPQPDVTP SPLSVRVSGS SGSTKEETQI PTSGSLLTEL QQVVQLQNYD
EEDDSLVVLP IFGESEDNDE YLDQVVTGEA ISVTMDNILS GFENEYDVIY LKPLAGVYRS
LKKQIEKNIF TFNLNLNDIL NSRLKKRKYF LDVLESDLMQ FKHISSNEYI IEDSFKLLNS
EQKNTLLKSY KYIKESVEND IKFAQEGISY YEKVLAKYKD DLESIKKVIK EEKEFPSSPP
TTPPSPAKTD EQKKESKFLP FLTNIETLYN NLVNKIDDYL INLKAKINDC NVEKDEAHVK
ITKLSDLKAI DDKIDLFKNP YDFEAIKKLI NDDTKKDMLG KLLSTGLVQN FPNTIISKLI
EGKFQDMLNI SQHQCVKKQC PQNSGCFRHL DEREECKCLL NYKQEGDKCV ENPNPTCNEN
NGGCDADAKC TEEDSGSNGK KITCECTKPD SYPLFDGIFC SSSNFLGISF LLILMLILYS
FI
