ID   MSP1_PLAFD              Reviewed;         233 AA.
AC   P13827;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Merozoite surface protein 1;
DE   AltName: Full=Glycoprotein 185;
DE            Short=GP185;
DE   AltName: Full=Merozoite surface antigens;
DE   AltName: Full=PMMSA;
DE   Flags: Precursor; Fragment;
GN   Name=MSP-1;
OS   Plasmodium falciparum (isolate CDC / Honduras).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5836;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3542719; DOI=10.1016/0378-1119(86)90404-x;
RA   Howard R.F., Ardeshir F., Reese R.T.;
RT   "Conservation and antigenicity of N-terminal sequences of GP185 from
RT   different Plasmodium falciparum isolates.";
RL   Gene 46:197-205(1986).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- PTM: Merozoite surface antigen contain the sequence of 83 kDa, 42 kDa
CC       and 19 kDa antigens which are the major surface antigens of merozoites.
CC       The maturation take place during schizont.
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DR   EMBL; M14632; AAB59227.1; -; mRNA.
DR   PIR; A25814; A25814.
DR   AlphaFoldDB; P13827; -.
DR   BMRB; P13827; -.
DR   SMR; P13827; -.
DR   DrugBank; DB11638; Artenimol.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Malaria; Membrane;
KW   Merozoite; Repeat; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..>233
FT                   /note="Merozoite surface protein 1"
FT                   /id="PRO_0000024549"
FT   REGION          58..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         233
SQ   SEQUENCE   233 AA;  26051 MW;  1DE4D31ACAEEE965 CRC64;
     MKIIFFLCSF LFFIINTQCV THESYQELVK KLEALEDAVL TGYSLFQKEK MVLNEGTSGT
     AVTTSTPGSK GSVASGGSGG SVASGGSVAS GGSGNSRRTN PSDNSSDSDA KSYADLKHRV
     RNYLLTIKEL KYPQLFDLTN HMLTLCDNIH GFKYLIDGYE EINELLYKLN FYFDLLRAKL
     NDVCANDYCQ IPFNLKIRAN ELDVLKKLVF GYRKPLDNIK DNVGKMEDYI KKK