MSP77_CAEEL
ID MSP77_CAEEL Reviewed; 127 AA.
AC Q9TVW5;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Major sperm protein 77/79;
DE Short=MSP;
GN Name=msp-77; ORFNames=F32B6.6;
GN and
GN Name=msp-79; ORFNames=T13F2.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Central component in molecular interactions underlying sperm
CC crawling. Forms an extensive filament system that extends from sperm
CC villipoda, along the leading edge of the pseudopod.
CC -!- SUBCELLULAR LOCATION: Cell projection, pseudopodium. Cytoplasm,
CC cytoskeleton.
CC -!- TISSUE SPECIFICITY: Sperm.
CC -!- MISCELLANEOUS: Around 30 MSP isoforms may exist in C.elegans.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z81074; CAB03037.1; -; Genomic_DNA.
DR EMBL; Z81122; CAB03361.1; -; Genomic_DNA.
DR PIR; T21640; T21640.
DR RefSeq; NP_501740.1; NM_069339.6.
DR RefSeq; NP_501781.1; NM_069380.3.
DR AlphaFoldDB; Q9TVW5; -.
DR SMR; Q9TVW5; -.
DR BioGRID; 42916; 1.
DR STRING; 6239.F32B6.6; -.
DR EPD; Q9TVW5; -.
DR PaxDb; Q9TVW5; -.
DR PeptideAtlas; Q9TVW5; -.
DR EnsemblMetazoa; F32B6.6.1; F32B6.6.1; WBGene00003464.
DR EnsemblMetazoa; T13F2.10.1; T13F2.10.1; WBGene00003466.
DR GeneID; 177812; -.
DR GeneID; 177844; -.
DR KEGG; cel:CELE_F32B6.6; -.
DR KEGG; cel:CELE_T13F2.10; -.
DR UCSC; T13F2.10; c. elegans.
DR CTD; 177812; -.
DR CTD; 177844; -.
DR WormBase; F32B6.6; CE09861; WBGene00003464; msp-77.
DR WormBase; T13F2.10; CE09861; WBGene00003466; msp-79.
DR eggNOG; ENOG502RXF6; Eukaryota.
DR GeneTree; ENSGT00970000195833; -.
DR HOGENOM; CLU_120664_0_1_1; -.
DR InParanoid; Q9TVW5; -.
DR OMA; NTPRREW; -.
DR OrthoDB; 1405423at2759; -.
DR PhylomeDB; Q9TVW5; -.
DR PRO; PR:Q9TVW5; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00003464; Expressed in adult organism and 2 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0001556; P:oocyte maturation; IDA:WormBase.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:WormBase.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:WormBase.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR Pfam; PF00635; Motile_Sperm; 1.
DR SUPFAM; SSF49354; SSF49354; 1.
DR PROSITE; PS50202; MSP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cell projection; Cytoplasm; Cytoskeleton; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..127
FT /note="Major sperm protein 77/79"
FT /id="PRO_0000213444"
FT DOMAIN 9..126
FT /note="MSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 127 AA; 14181 MW; 69F6962335A5B147 CRC64;
MAQSVPPGDI QTQPGTKIVF NAPYDDKHTY HIKVINSSAR RIGYGIKTTN MKRLGVDPPC
GVLDPKEAVL LAVSCDAFAF GQEDTNNDRI TVEWTNTPDG AAKQFRREWF QGDGMARRKN
LPIEYNP
