ID   MSPD1_BOVIN             Reviewed;         213 AA.
AC   Q2T9W7;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Motile sperm domain-containing protein 1;
GN   Name=MOSPD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in differentiation and/or proliferation of
CC       mesenchymal stem cells. Proposed to be involved in epithelial-to-
CC       mesenchymal transition (EMT). However, another study suggests that it
CC       is not required for EMT or stem cell self-renewal and acts during later
CC       stages of differentiation. {ECO:0000250|UniProtKB:Q8VEL0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8VEL0}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8VEL0};
CC       Multi-pass membrane protein {ECO:0000255}.
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DR   EMBL; BC111231; AAI11232.1; -; mRNA.
DR   RefSeq; NP_001033226.1; NM_001038137.1.
DR   AlphaFoldDB; Q2T9W7; -.
DR   SMR; Q2T9W7; -.
DR   STRING; 9913.ENSBTAP00000018489; -.
DR   PaxDb; Q2T9W7; -.
DR   Ensembl; ENSBTAT00000018489; ENSBTAP00000018489; ENSBTAG00000013922.
DR   GeneID; 523578; -.
DR   KEGG; bta:523578; -.
DR   CTD; 56180; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013922; -.
DR   VGNC; VGNC:31564; MOSPD1.
DR   eggNOG; KOG0439; Eukaryota.
DR   GeneTree; ENSGT00940000155266; -.
DR   HOGENOM; CLU_088040_0_0_1; -.
DR   InParanoid; Q2T9W7; -.
DR   OMA; KVLCNAP; -.
DR   OrthoDB; 1197131at2759; -.
DR   TreeFam; TF319778; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000013922; Expressed in oocyte and 105 other tissues.
DR   ExpressionAtlas; Q2T9W7; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR039283; MOSPD1.
DR   InterPro; IPR000535; MSP_dom.
DR   InterPro; IPR008962; PapD-like_sf.
DR   PANTHER; PTHR34441; PTHR34441; 1.
DR   Pfam; PF00635; Motile_Sperm; 1.
DR   SUPFAM; SSF49354; SSF49354; 1.
DR   PROSITE; PS50202; MSP; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..213
FT                   /note="Motile sperm domain-containing protein 1"
FT                   /id="PRO_0000248063"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          16..143
FT                   /note="MSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT   MOTIF           205..208
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q8VEL0"
SQ   SEQUENCE   213 AA;  24226 MW;  A313283428ED046D CRC64;
     MHQQKRQPEL VEGNLPVFVF PTELIFYADD QSTHKQVLTL YNPYEFALKF KVLCTTPNKY
     VVVDAAGAVK PQCCMDIVIR HRDVRSCHYG VIDKFRLQVS EQSQRKALGR KEVVATLLPS
     AKEQQKEEEE KRIKEHLTES LFFEQSFQPE NRTVSSGPSL LTVFLAVVCI TALMLPTLGD
     VESLVPLYLH LSVNQKLVAA YILGLITMAI FRT