ID   MSPD1_RAT               Reviewed;         213 AA.
AC   Q5RJS6;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Motile sperm domain-containing protein 1;
GN   Name=Mospd1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in differentiation and/or proliferation of
CC       mesenchymal stem cells. Proposed to be involved in epithelial-to-
CC       mesenchymal transition (EMT). However, another study suggests that it
CC       is not required for EMT or stem cell self-renewal and acts during later
CC       stages of differentiation. {ECO:0000250|UniProtKB:Q8VEL0}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q8VEL0}; Multi-pass membrane protein
CC       {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8VEL0};
CC       Multi-pass membrane protein {ECO:0000255}.
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DR   EMBL; BC086521; AAH86521.1; -; mRNA.
DR   RefSeq; NP_001014129.1; NM_001014107.1.
DR   RefSeq; XP_006251462.1; XM_006251400.3.
DR   RefSeq; XP_006257695.1; XM_006257633.3.
DR   AlphaFoldDB; Q5RJS6; -.
DR   SMR; Q5RJS6; -.
DR   STRING; 10116.ENSRNOP00000003192; -.
DR   PhosphoSitePlus; Q5RJS6; -.
DR   PaxDb; Q5RJS6; -.
DR   GeneID; 317312; -.
DR   GeneID; 686087; -.
DR   KEGG; rno:317312; -.
DR   KEGG; rno:686087; -.
DR   CTD; 56180; -.
DR   RGD; 1359486; Mospd1.
DR   VEuPathDB; HostDB:ENSRNOG00000058316; -.
DR   VEuPathDB; HostDB:ENSRNOG00000066239; -.
DR   eggNOG; KOG0439; Eukaryota.
DR   HOGENOM; CLU_088040_0_0_1; -.
DR   InParanoid; Q5RJS6; -.
DR   OMA; KVLCNAP; -.
DR   OrthoDB; 1197131at2759; -.
DR   PhylomeDB; Q5RJS6; -.
DR   TreeFam; TF319778; -.
DR   PRO; PR:Q5RJS6; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000002332; Expressed in heart and 17 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR039283; MOSPD1.
DR   InterPro; IPR000535; MSP_dom.
DR   InterPro; IPR008962; PapD-like_sf.
DR   PANTHER; PTHR34441; PTHR34441; 1.
DR   Pfam; PF00635; Motile_Sperm; 1.
DR   SUPFAM; SSF49354; SSF49354; 1.
DR   PROSITE; PS50202; MSP; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Golgi apparatus; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..213
FT                   /note="Motile sperm domain-containing protein 1"
FT                   /id="PRO_0000213462"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        191..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          16..143
FT                   /note="MSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT   MOTIF           205..208
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q8VEL0"
SQ   SEQUENCE   213 AA;  24088 MW;  C1139A6A1BD92CA9 CRC64;
     MHQQKRQPEL VEGNLPVFVF PTELIFYADD QSTHKQVLTL YNPYEFALKF KVLCTTPNKY
     VVIDAAGAVK PQCCVDIVIR HRDVRSCHYG VIDKFRLQVS EQSQRKALGR KEVIATLLPS
     AKEQQKEEEE KRIKEHLTES VFFEQSCQPE NRAVSSGPSL LTVFLGVVCI AALMLPTLGD
     MESLVPLYLH LSVNQKLVAA YILGLITMAI LRT