MSPD3_MOUSE
ID MSPD3_MOUSE Reviewed; 235 AA.
AC Q8BGG6;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Motile sperm domain-containing protein 3;
GN Name=Mospd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY, AND DISEASE.
RX PubMed=15533722; DOI=10.1016/j.ygeno.2004.08.017;
RA Pall G.S., Wallis J., Axton R., Brownstein D.G., Gautier P., Buerger K.,
RA Mulford C., Mullins J.J., Forrester L.M.;
RT "A novel transmembrane MSP-containing protein that plays a role in right
RT ventricle development.";
RL Genomics 84:1051-1059(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in heart, kidney, liver, spleen and brain.
CC {ECO:0000269|PubMed:15533722}.
CC -!- DISEASE: Note=Defects in Mospd3 are a cause of defects of the right
CC heart ventricle and of high mortality in newborns.
CC {ECO:0000269|PubMed:15533722}.
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DR EMBL; BC039620; AAH39620.1; -; mRNA.
DR EMBL; AK088731; BAC40534.1; -; mRNA.
DR CCDS; CCDS19771.1; -.
DR RefSeq; NP_001241691.1; NM_001254762.1.
DR RefSeq; NP_084313.1; NM_030037.2.
DR RefSeq; XP_006504677.1; XM_006504614.3.
DR AlphaFoldDB; Q8BGG6; -.
DR SMR; Q8BGG6; -.
DR STRING; 10090.ENSMUSP00000040828; -.
DR PhosphoSitePlus; Q8BGG6; -.
DR EPD; Q8BGG6; -.
DR MaxQB; Q8BGG6; -.
DR PaxDb; Q8BGG6; -.
DR PRIDE; Q8BGG6; -.
DR ProteomicsDB; 291448; -.
DR Antibodypedia; 30772; 123 antibodies from 24 providers.
DR Ensembl; ENSMUST00000037620; ENSMUSP00000040828; ENSMUSG00000037221.
DR Ensembl; ENSMUST00000111007; ENSMUSP00000106636; ENSMUSG00000037221.
DR GeneID; 68929; -.
DR KEGG; mmu:68929; -.
DR UCSC; uc009acz.1; mouse.
DR CTD; 64598; -.
DR MGI; MGI:1916179; Mospd3.
DR VEuPathDB; HostDB:ENSMUSG00000037221; -.
DR eggNOG; KOG0439; Eukaryota.
DR GeneTree; ENSGT00940000162123; -.
DR HOGENOM; CLU_088040_0_0_1; -.
DR InParanoid; Q8BGG6; -.
DR OMA; FRIELSQ; -.
DR OrthoDB; 1197131at2759; -.
DR PhylomeDB; Q8BGG6; -.
DR TreeFam; TF319778; -.
DR BioGRID-ORCS; 68929; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Mospd3; mouse.
DR PRO; PR:Q8BGG6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8BGG6; protein.
DR Bgee; ENSMUSG00000037221; Expressed in embryonic brain and 132 other tissues.
DR ExpressionAtlas; Q8BGG6; baseline and differential.
DR Genevisible; Q8BGG6; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; ISS:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0033149; F:FFAT motif binding; IBA:GO_Central.
DR GO; GO:0090158; P:endoplasmic reticulum membrane organization; IBA:GO_Central.
DR GO; GO:0061817; P:endoplasmic reticulum-plasma membrane tethering; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000535; MSP_dom.
DR InterPro; IPR008962; PapD-like_sf.
DR InterPro; IPR016763; VAP.
DR PANTHER; PTHR10809; PTHR10809; 1.
DR Pfam; PF00635; Motile_Sperm; 1.
DR SUPFAM; SSF49354; SSF49354; 1.
DR PROSITE; PS50202; MSP; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..235
FT /note="Motile sperm domain-containing protein 3"
FT /id="PRO_0000213466"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 33..145
FT /note="MSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00132"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 235 AA; 25433 MW; 9B809C6DA07F30C6 CRC64;
MRRGAPQDQE LVGPGAPGRG SRGSPPSSGP VVPVLVFPPD LVFRADQRSG PRQLLTLYNP
TGTALRFRVL CTAPAKYTVF DAEGYVKPQS CIDIVIRHVA PVPSHYDVQD RFRIELSEEG
TEGRVVGRKD ITSVLRAPAY PLELQGHSEP TPNPGPPVWT GLTPARHLQE NAPQQLATSS
FLLFLLAGVI SVAFLLLPLQ DELGSQLPQV LHVSLGQKLV AAYVLGLLTM VLLRT
