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MSPD_MYCS2
ID   MSPD_MYCS2              Reviewed;         207 AA.
AC   A0R541; I7FM03; Q934G1;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Porin MspD;
DE   Flags: Precursor;
GN   Name=mspD; OrderedLocusNames=MSMEG_6057, MSMEI_5897;
OS   Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium
OS   smegmatis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=246196;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=11309127; DOI=10.1046/j.1365-2958.2001.02394.x;
RA   Stahl C., Kubetzko S., Kaps I., Seeber S., Engelhardt H., Niederweis M.;
RT   "MspA provides the main hydrophilic pathway through the cell wall of
RT   Mycobacterium smegmatis.";
RL   Mol. Microbiol. 40:451-464(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RA   Fleischmann R.D., Dodson R.J., Haft D.H., Merkel J.S., Nelson W.C.,
RA   Fraser C.M.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=17295914; DOI=10.1186/gb-2007-8-2-r20;
RA   Deshayes C., Perrodou E., Gallien S., Euphrasie D., Schaeffer C.,
RA   Van-Dorsselaer A., Poch O., Lecompte O., Reyrat J.-M.;
RT   "Interrupted coding sequences in Mycobacterium smegmatis: authentic
RT   mutations or sequencing errors?";
RL   Genome Biol. 8:R20.1-R20.9(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=18955433; DOI=10.1101/gr.081901.108;
RA   Gallien S., Perrodou E., Carapito C., Deshayes C., Reyrat J.-M.,
RA   Van Dorsselaer A., Poch O., Schaeffer C., Lecompte O.;
RT   "Ortho-proteogenomics: multiple proteomes investigation through orthology
RT   and a new MS-based protocol.";
RL   Genome Res. 19:128-135(2009).
RN   [5]
RP   FUNCTION AS A PORIN, INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700084 / mc(2)155;
RX   PubMed=16238622; DOI=10.1111/j.1365-2958.2005.04878.x;
RA   Stephan J., Bender J., Wolschendorf F., Hoffmann C., Roth E., Mailander C.,
RA   Engelhardt H., Niederweis M.;
RT   "The growth rate of Mycobacterium smegmatis depends on sufficient porin-
RT   mediated influx of nutrients.";
RL   Mol. Microbiol. 58:714-730(2005).
CC   -!- FUNCTION: A backup porin induced when MspA, the major porin, is
CC       deleted. It probably forms a water-filled channel which favors the
CC       permeation of cations. There are about 2400 porins in wild-type, 800 in
CC       an mspA deletion and 150 in a double mspA-mspC deletion.
CC       {ECO:0000269|PubMed:16238622}.
CC   -!- SUBUNIT: Octamers. Probably forms a goblet with the wide end on the
CC       exterior of the outer membrane and a central channel. It is not known
CC       if mixed oligomers of MspD with other Msp subunits form in vivo (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}. Secreted, cell
CC       wall {ECO:0000250}.
CC   -!- INDUCTION: Not expressed in wild-type cells, it is induced in an mspA
CC       deletion mutant. {ECO:0000269|PubMed:16238622}.
CC   -!- DISRUPTION PHENOTYPE: Single deletion is viable. A triple mspA-mspC-
CC       mspD deletion grows slower than the single mspA or double mspA-mspC
CC       deletions and has reduced Fe(3+) transport compared to wild-type.
CC       {ECO:0000269|PubMed:16238622}.
CC   -!- SIMILARITY: Belongs to the mycobacterial porin (TC 1.B.24) family.
CC       {ECO:0000305}.
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DR   EMBL; AJ300774; CAC83628.1; -; Genomic_DNA.
DR   EMBL; CP000480; ABK72453.1; -; Genomic_DNA.
DR   EMBL; CP001663; AFP42330.1; -; Genomic_DNA.
DR   RefSeq; YP_890279.1; NC_008596.1.
DR   AlphaFoldDB; A0R541; -.
DR   SMR; A0R541; -.
DR   STRING; 246196.MSMEI_5897; -.
DR   EnsemblBacteria; ABK72453; ABK72453; MSMEG_6057.
DR   EnsemblBacteria; AFP42330; AFP42330; MSMEI_5897.
DR   KEGG; msg:MSMEI_5897; -.
DR   KEGG; msm:MSMEG_6057; -.
DR   PATRIC; fig|246196.19.peg.5895; -.
DR   eggNOG; ENOG5031B57; Bacteria.
DR   OMA; DITQPPF; -.
DR   Proteomes; UP000000757; Chromosome.
DR   Proteomes; UP000006158; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR036435; Leukocidin/porin_MspA_sf.
DR   InterPro; IPR015286; Porin_fam_mycobact-type.
DR   Pfam; PF09203; MspA; 1.
DR   SUPFAM; SSF56959; SSF56959; 1.
PE   1: Evidence at protein level;
KW   Cell outer membrane; Cell wall; Ion transport; Membrane; Porin;
KW   Reference proteome; Secreted; Signal; Transmembrane;
KW   Transmembrane beta strand; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..207
FT                   /note="Porin MspD"
FT                   /id="PRO_5000066832"
SQ   SEQUENCE   207 AA;  21886 MW;  19179E049C32C8D2 CRC64;
     MRYLVMMFAL LVSVTLVSPR PANAVDNQLS VVDGQGRTLT VQQAETFLNG VFPLDRNRLT
     REWFHSGRAT YHVAGPGADE FEGTLELGYQ VGFPWSLGVG INFSYTTPNI LIDGGDITQP
     PFGLDTIITP NLFPGVSISA DLGNGPGIQE VATFSVDVKG AKGAVAVSNA HGTVTGAAGG
     VLLRPFARLI ASTGDSVTTY GEPWNMN
 
 
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