ID   MSP_DICDI               Reviewed;         243 AA.
AC   Q86KP5; Q550V4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=Membrane selenoprotein;
GN   Name=msp; ORFNames=DDB_G0277015;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000019; EAL69009.2; -; Genomic_DNA.
DR   RefSeq; XP_642828.2; XM_637736.2.
DR   PaxDb; Q86KP5; -.
DR   EnsemblProtists; EAL69009; EAL69009; DDB_G0277015.
DR   GeneID; 8620691; -.
DR   KEGG; ddi:DDB_G0277015; -.
DR   dictyBase; DDB_G0277015; msp.
DR   eggNOG; ENOG502SFFE; Eukaryota.
DR   HOGENOM; CLU_1144336_0_0_1; -.
DR   InParanoid; Q86KP5; -.
DR   OMA; FGPFYLT; -.
DR   PRO; PR:Q86KP5; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016259; P:selenocysteine metabolic process; IDA:dictyBase.
PE   4: Predicted;
KW   Membrane; Reference proteome; Selenocysteine; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..243
FT                   /note="Membrane selenoprotein"
FT                   /id="PRO_0000370854"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        199..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          12..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..61
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_STD         20
FT                   /note="Selenocysteine"
FT   NON_STD         88
FT                   /note="Selenocysteine"
SQ   SEQUENCE   243 AA;  26526 MW;  B53CBF1D94B46940 CRC64;
     MSLFNLPKVD LGEDCEGGVU ARPSSSSSSI NNASDESTPL ISKTNDEEKA NIGISSTSNS
     PQEEQTKKPL FISILTLLIS IPALVGSUCW PVLIASLSGV AVSAGSVELA HSLTFAITLS
     ILSNLAQYHF HKCKKRPSDR GHWIKFGPFY LTAIAVPLAT FDILRHILVD NSIWTIHSFI
     SPAAYRPGCE NENITCLSVM GWFSAIVFTY TGYACLLVGT IWAADLIPKI KKVWTQLRPS
     KKN