MSP_MESAU
ID MSP_MESAU Reviewed; 172 AA.
AC Q9QXU1;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Male-specific submandibular salivary gland protein {ECO:0000303|PubMed:15950295};
DE Flags: Precursor;
GN Name=MSP {ECO:0000303|PubMed:15950295};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000312|EMBL:AAD55792.2};
RN [1] {ECO:0000312|EMBL:AAD55792.2}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-30, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, AND
RP GLYCOSYLATION.
RC TISSUE=Submandibular gland {ECO:0000303|PubMed:10561587};
RX PubMed=10561587; DOI=10.1046/j.1432-1327.1999.00884.x;
RA Thavathiru E., Jana N.R., De P.K.;
RT "Abundant secretory lipocalins displaying male and lactation-specific
RT expression in adult hamster submandibular gland. cDNA cloning and sex
RT hormone-regulated repression.";
RL Eur. J. Biochem. 266:467-476(1999).
RN [2] {ECO:0000312|EMBL:AAD55792.2}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 16-30, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, INDUCTION, AND GLYCOSYLATION.
RC TISSUE=Lacrimal gland {ECO:0000312|EMBL:AAD55792.2}, and
RC Submandibular gland {ECO:0000303|PubMed:15950295};
RX PubMed=15950295; DOI=10.1016/j.bbaexp.2005.04.008;
RA Srikantan S., Parekh V., De P.K.;
RT "cDNA cloning and regulation of two sex-hormone-repressed hamster tear
RT lipocalins having homology with odorant/pheromone-binding proteins.";
RL Biochim. Biophys. Acta 1729:154-165(2005).
RN [3] {ECO:0000312|EMBL:AAM00936.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Parekh V., Srikantan S., De P.K.;
RT "Cloning and characterization of a gene encoding the male-specific
RT submandibular gland protein (MSP) of hamster.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=8809199; DOI=10.1016/0960-0760(96)00024-6;
RA De P.K.;
RT "Sex-hormonal regulation of 20.5 and 24 kDa major male-specific proteins in
RT Syrian hamster submandibular gland.";
RL J. Steroid Biochem. Mol. Biol. 58:183-187(1996).
RN [5] {ECO:0000305}
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17316636; DOI=10.1016/j.ygcen.2007.01.003;
RA Srikantan S., Paliwal A., Quintanar-Stephano A., De P.K.;
RT "Estrogen and androgen repression of two female specific lacrimal
RT lipocalins in hamster: Pituitary independent and sex hormone receptor
RT mediated action.";
RL Gen. Comp. Endocrinol. 151:172-179(2007).
RN [6] {ECO:0000305}
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=18703064; DOI=10.1016/j.ygcen.2008.07.019;
RA Srikantan S., De P.K.;
RT "Sex differences in expression and differential regulation by androgen and
RT estrogen of two odorant-binding tear lipocalins in lacrimal glands of
RT immature hamsters.";
RL Gen. Comp. Endocrinol. 158:268-276(2008).
RN [7] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=23453961; DOI=10.1016/j.ygcen.2013.02.016;
RA Dubey V.P., Srikantan S., Mohammad M.P., Rajan W.D., De P.K.;
RT "Copious urinary excretion of a male Syrian hamster (Mesocricetus auratus)
RT salivary gland protein after its endocrine-like release upon beta-
RT adrenergic stimulation.";
RL Gen. Comp. Endocrinol. 186:25-32(2013).
RN [8] {ECO:0000305}
RP ALLERGEN.
RX PubMed=25765367; DOI=10.1159/000371420;
RA Hilger C., Dubey V.P., Lentz D., Davril C., Revets D., Muller C.P.,
RA Diederich C., De La Barriere H., Codreanu-Morel F., Morisset M.,
RA Lehners C., De P.K., Hentges F.;
RT "Male-specific submaxillary gland protein, a lipocalin allergen of the
RT golden hamster, differs from the lipocalin allergens of siberian and
RT roborovski dwarf hamsters.";
RL Int. Arch. Allergy Immunol. 166:30-40(2015).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10561587,
CC ECO:0000269|PubMed:15950295}. Cytoplasm {ECO:0000269|PubMed:23453961}.
CC Note=Located in the cytoplasm of acinar cells in the submandibular
CC salivary gland from where it is secreted into saliva (PubMed:10561587,
CC PubMed:23453961). Secreted by the lacrimal gland into tears
CC (PubMed:15950295). Also secreted by the submandibular salivary gland
CC into circulation and excreted in urine (PubMed:10561587,
CC PubMed:23453961). {ECO:0000269|PubMed:10561587,
CC ECO:0000269|PubMed:15950295, ECO:0000269|PubMed:23453961}.
CC -!- TISSUE SPECIFICITY: Expressed in acinar cells of the submandibular
CC salivary gland from where it is secreted into saliva (at protein level)
CC (PubMed:10561587, PubMed:8809199, PubMed:23453961). Also released from
CC the submandibular salivary gland into blood and excreted in urine (at
CC protein level) (PubMed:23453961). Expressed in the lacrimal gland from
CC where it is secreted into tears (at protein level) (PubMed:15950295,
CC PubMed:17316636, PubMed:18703064). {ECO:0000269|PubMed:10561587,
CC ECO:0000269|PubMed:15950295, ECO:0000269|PubMed:17316636,
CC ECO:0000269|PubMed:18703064, ECO:0000269|PubMed:23453961,
CC ECO:0000269|PubMed:8809199}.
CC -!- DEVELOPMENTAL STAGE: In the submandibular salivary gland, expression is
CC very low in immature animals of both sexes with trace levels at 12 days
CC of age. At 22 and 30 days of age, low levels occur in the submandibular
CC salivary gland of both sexes with females having higher levels than
CC males. At the onset of sexual maturity, abundantly expressed in males
CC and undetectable in non-lactating females but is expressed in lactating
CC females (at protein level) (PubMed:10561587). In the lacrimal gland,
CC detectable in both sexes at 10 days of age but, by 20 days of age,
CC expression is female-specific with no detectable expression in males
CC (PubMed:18703064). {ECO:0000269|PubMed:10561587,
CC ECO:0000269|PubMed:18703064}.
CC -!- INDUCTION: Repressed by androgens and estrogens (at protein level)
CC (PubMed:10561587, PubMed:15950295, PubMed:8809199, PubMed:17316636).
CC Repression by estrogens and androgens does not occur in immature 20-day
CC old animals (PubMed:18703064). {ECO:0000269|PubMed:10561587,
CC ECO:0000269|PubMed:15950295, ECO:0000269|PubMed:17316636,
CC ECO:0000269|PubMed:18703064, ECO:0000269|PubMed:8809199}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:10561587,
CC ECO:0000269|PubMed:15950295}.
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC {ECO:0000269|PubMed:25765367}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000255|RuleBase:RU003695}.
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DR EMBL; AF183407; AAD55792.2; -; mRNA.
DR EMBL; AF491999; AAM00936.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9QXU1; -.
DR SMR; Q9QXU1; -.
DR Allergome; 11698; Mes a 1.
DR Allergome; 11699; Mes a 1.0101.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002448; OBP-like.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01173; ODORANTBNDNG.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 1: Evidence at protein level;
KW Allergen; Cytoplasm; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..15
FT /evidence="ECO:0000269|PubMed:15950295"
FT CHAIN 16..172
FT /note="Male-specific submandibular salivary gland protein"
FT /evidence="ECO:0000305"
FT /id="PRO_5000057056"
FT CARBOHYD 41
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT DISULFID 60..64
FT /evidence="ECO:0000250|UniProtKB:P08937"
FT DISULFID 79..170
FT /evidence="ECO:0000250|UniProtKB:P08937"
SQ SEQUENCE 172 AA; 19375 MW; 105EE6D7087181EC CRC64;
MVKFLLLALA LGVSCAQHQN LEVSPSEVDG KWHSLYIAAD NKSKVSEGGP LRVYVKHLEC
SDECQTFTIK FYTKVENVCQ EHRVVGRKGK DGKYITDFSG QNYFHVVEKA DDTMTFHNVN
VDDSGKTNVI LVVGKGESSS IEQKQRFEKT AEKYDIPKEN IEHLVTTDTC NQ
