位置:首页 > 蛋白库 > MSRA1_LACLA
MSRA1_LACLA
ID   MSRA1_LACLA             Reviewed;         183 AA.
AC   Q9CFC8;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Peptide methionine sulfoxide reductase MsrA 1;
DE            Short=Protein-methionine-S-oxide reductase 1;
DE            EC=1.8.4.11;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase 1;
DE            Short=Peptide Met(O) reductase 1;
GN   Name=msrA1; Synonyms=pmsX; OrderedLocusNames=LL1553; ORFNames=L193644;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Has an important function as a repair enzyme for proteins
CC       that have been inactivated by oxidation. Catalyzes the reversible
CC       oxidation-reduction of methionine sulfoxide in proteins to methionine
CC       (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] =
CC         [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein];
CC         Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700,
CC         Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120,
CC         ChEBI:CHEBI:50058; EC=1.8.4.11;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-
CC         dithiol + L-methionine (S)-S-oxide; Xref=Rhea:RHEA:19993, Rhea:RHEA-
CC         COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844,
CC         ChEBI:CHEBI:58772; EC=1.8.4.11;
CC   -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005176; AAK05651.1; -; Genomic_DNA.
DR   PIR; A86819; A86819.
DR   RefSeq; NP_267709.1; NC_002662.1.
DR   RefSeq; WP_003130680.1; NC_002662.1.
DR   AlphaFoldDB; Q9CFC8; -.
DR   SMR; Q9CFC8; -.
DR   STRING; 272623.L193644; -.
DR   PaxDb; Q9CFC8; -.
DR   EnsemblBacteria; AAK05651; AAK05651; L193644.
DR   KEGG; lla:L193644; -.
DR   PATRIC; fig|272623.7.peg.1667; -.
DR   eggNOG; COG0225; Bacteria.
DR   HOGENOM; CLU_031040_10_0_9; -.
DR   OMA; GYCAFVV; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0033744; F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity; IEA:RHEA.
DR   GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1060.10; -; 1.
DR   HAMAP; MF_01401; MsrA; 1.
DR   InterPro; IPR002569; Met_Sox_Rdtase_MsrA_dom.
DR   InterPro; IPR036509; Met_Sox_Rdtase_MsrA_sf.
DR   Pfam; PF01625; PMSR; 1.
DR   SUPFAM; SSF55068; SSF55068; 1.
DR   TIGRFAMs; TIGR00401; msrA; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..183
FT                   /note="Peptide methionine sulfoxide reductase MsrA 1"
FT                   /id="PRO_0000138551"
FT   ACT_SITE        12
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   183 AA;  21331 MW;  D052F9F74B0E04F4 CRC64;
     MSTERAIFAG GCFWCMVEPF EERPGILAVT SGYTGGHIEY PTYDQVLSKA SGHTEAVEIL
     FDNELISYDE LLDIYWSLID PTDADGQIYD RGANYRPVIF VESEEQRIAA QKSKIALEKS
     GIWDKPIVVP IEEAKTFWPA EEYHQQYYKK DPKRYQAMHK ARERYLALQR FKGKFKFLRK
     NTR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024