MSRA_SOLLC
ID MSRA_SOLLC Reviewed; 196 AA.
AC P54153;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Peptide methionine sulfoxide reductase;
DE EC=1.8.4.11;
DE AltName: Full=Fruit-ripening protein E4;
DE AltName: Full=Peptide-methionine (S)-S-oxide reductase;
DE Short=Peptide Met(O) reductase;
DE AltName: Full=Protein-methionine-S-oxide reductase;
DE Flags: Fragment;
GN Name=E4;
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2562553; DOI=10.2307/3869003;
RA Cordes S., Deikman J., Margossian L.J., Fischer R.L.;
RT "Interaction of a developmentally regulated DNA-binding factor with sites
RT flanking two different fruit-ripening genes from tomato.";
RL Plant Cell 1:1025-1034(1989).
CC -!- FUNCTION: Has an important function as a repair enzyme for proteins
CC that have been inactivated by oxidation. Catalyzes the reversible
CC oxidation-reduction of methionine sulfoxide in proteins to methionine
CC (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] =
CC [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein];
CC Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700,
CC Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120,
CC ChEBI:CHEBI:50058; EC=1.8.4.11;
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-
CC dithiol + L-methionine (S)-S-oxide; Xref=Rhea:RHEA:19993, Rhea:RHEA-
CC COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844,
CC ChEBI:CHEBI:58772; EC=1.8.4.11;
CC -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
CC {ECO:0000305}.
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DR EMBL; S44898; AAB23481.2; -; Genomic_DNA.
DR PIR; JQ0988; JQ0988.
DR RefSeq; NP_001307131.1; NM_001320202.1.
DR AlphaFoldDB; P54153; -.
DR SMR; P54153; -.
DR STRING; 4081.Solyc03g111720.2.1; -.
DR PaxDb; P54153; -.
DR PRIDE; P54153; -.
DR EnsemblPlants; Solyc03g111720.3.1; Solyc03g111720.3.1; Solyc03g111720.3.
DR GeneID; 101253577; -.
DR Gramene; Solyc03g111720.3.1; Solyc03g111720.3.1; Solyc03g111720.3.
DR KEGG; sly:101253577; -.
DR eggNOG; KOG1635; Eukaryota.
DR HOGENOM; CLU_031040_3_0_1; -.
DR InParanoid; P54153; -.
DR OMA; AGPFYYA; -.
DR OrthoDB; 1383773at2759; -.
DR PhylomeDB; P54153; -.
DR BRENDA; 1.8.4.11; 3101.
DR Proteomes; UP000004994; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0036456; F:L-methionine-(S)-S-oxide reductase activity; IBA:GO_Central.
DR GO; GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity; IBA:GO_Central.
DR GO; GO:0034599; P:cellular response to oxidative stress; IBA:GO_Central.
DR Gene3D; 3.30.1060.10; -; 1.
DR HAMAP; MF_01401; MsrA; 1.
DR InterPro; IPR002569; Met_Sox_Rdtase_MsrA_dom.
DR InterPro; IPR036509; Met_Sox_Rdtase_MsrA_sf.
DR Pfam; PF01625; PMSR; 1.
DR SUPFAM; SSF55068; SSF55068; 1.
DR TIGRFAMs; TIGR00401; msrA; 1.
PE 3: Inferred from homology;
KW Oxidoreductase; Reference proteome.
FT CHAIN 1..>196
FT /note="Peptide methionine sulfoxide reductase"
FT /id="PRO_0000138636"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 196
SQ SEQUENCE 196 AA; 21918 MW; FD251E1A6A123423 CRC64;
MEGNNSSSKS TTNPALDPDL DSPDQPGLEF AQFAAGCFWG VELAFQRVGG VVKTEVGYSQ
GNVHDPNYKL ICSGTTEHAE AIRIQFDPNV CPYSNLLSLF WSRHDPTTLN RQGNDVGKQY
RSGIYYYNDA QAQLARESLE AKQKEFMDKK IVTEILPAKR FYRAEEYHQQ YLEKGGGRGC
KQSAAKGCND PIRCYG
