ID   AROA_BURPE              Reviewed;         463 AA.
AC   P39915;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 2.
DT   07-APR-2021, entry version 102.
DE   RecName: Full=3-phosphoshikimate 1-carboxyvinyltransferase;
DE            EC=2.5.1.19;
DE   AltName: Full=5-enolpyruvylshikimate-3-phosphate synthase;
DE            Short=EPSP synthase;
DE            Short=EPSPS;
GN   Name=aroA;
OS   Burkholderia pseudomallei (Pseudomonas pseudomallei).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=28450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Penaloza-Vazquez A., Bailey A.M.;
RT   "Cloning and sequencing of the aroA gene from Pseudomonas pseudomallei.";
RL   Submitted (DEC-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-
CC         carboxyvinyl)-3-phosphoshikimate + phosphate; Xref=Rhea:RHEA:21256,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57701, ChEBI:CHEBI:58702,
CC         ChEBI:CHEBI:145989; EC=2.5.1.19;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       6/7.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EPSP synthase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA54317.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X77019; CAA54317.1; ALT_FRAME; Genomic_DNA.
DR   UniPathway; UPA00053; UER00089.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003866; F:3-phosphoshikimate 1-carboxyvinyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd01556; EPSP_synthase; 1.
DR   Gene3D; 3.65.10.10; -; 2.
DR   InterPro; IPR001986; Enolpyruvate_Tfrase_dom.
DR   InterPro; IPR036968; Enolpyruvate_Tfrase_sf.
DR   InterPro; IPR006264; EPSP_synthase.
DR   InterPro; IPR023193; EPSP_synthase_CS.
DR   InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR   Pfam; PF00275; EPSP_synthase; 1.
DR   SUPFAM; SSF55205; SSF55205; 1.
DR   TIGRFAMs; TIGR01356; aroA; 1.
DR   PROSITE; PS00104; EPSP_SYNTHASE_1; 1.
DR   PROSITE; PS00885; EPSP_SYNTHASE_2; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Cytoplasm;
KW   Transferase.
FT   CHAIN           1..463
FT                   /note="3-phosphoshikimate 1-carboxyvinyltransferase"
FT                   /id="PRO_0000088239"
SQ   SEQUENCE   463 AA;  49536 MW;  C164DE1812F5B89B CRC64;
     MAFQWPRFPL QPWRHVTGHL RLPGDKSISN RSLLLGALAE GVTEVTGLLD SDDARAMLNA
     LRDLGVVIEG PHQGRCTVHG VGLHGLKAPP GPLFLGNAGT AMRPLSAALA LQPFDTTLTG
     DPRMSERPIN RLVDALREMG AVIEYLAQEG YPPLTIRGGG SVSSQFLTAL LMTAPMASAQ
     IKSGLLLSKP YIDITLNVMP FGVPTRDHTE RIFAVSAIRY PSPAVLRLEG DATSASYFLA
     AAGIKGVPVT GIGRHSMQGD SWFPRALRRM GARSCGSSMI VCPRGELRAA VRSDSNSIPD
     AAMTLATXXA LARGGRRPRT IFAWRVKETD RLYAMSTELG AAGARVVPGA GLRGCPLRGR
     SYYVARCRRD SRMAMCFSLP AHGGRAVRHP GSRLHRQDAE LSSKVVRSVP EVWGMAITAL
     RCPSGGALRA MARFESMTGQ RGDVVSQLPL LGAARRHAGT FGG