ID   MSRR_STAA8              Reviewed;         327 AA.
AC   Q7BHL7; Q2G2L9;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Regulatory protein MsrR;
GN   Name=msrR; OrderedLocusNames=SAOUHSC_01361;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RX   PubMed=12878519; DOI=10.1128/aac.47.8.2558-2564.2003;
RA   Rossi J., Bischoff M., Wada A., Berger-Baechi B.;
RT   "MsrR, a putative cell envelope-associated element involved in
RT   Staphylococcus aureus sarA attenuation.";
RL   Antimicrob. Agents Chemother. 47:2558-2564(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC       and teicoplanin, as well as the synthesis of virulence factors.
CC       {ECO:0000269|PubMed:12878519}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Expression peaks in the early exponential growth
CC       phase and decreases towards the late exponential and stationary phases.
CC   -!- INDUCTION: Induced by cell wall-active agents, such as beta-lactams,
CC       glycopeptides, bacitracin, fosfomycin and lysostaphin.
CC       {ECO:0000269|PubMed:12878519}.
CC   -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family. {ECO:0000305}.
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DR   EMBL; AF311784; AAK00895.1; -; Genomic_DNA.
DR   EMBL; CP000253; ABD30456.1; -; Genomic_DNA.
DR   RefSeq; WP_000356975.1; NZ_LS483365.1.
DR   RefSeq; YP_499888.1; NC_007795.1.
DR   AlphaFoldDB; Q7BHL7; -.
DR   SMR; Q7BHL7; -.
DR   STRING; 1280.SAXN108_1378; -.
DR   EnsemblBacteria; ABD30456; ABD30456; SAOUHSC_01361.
DR   GeneID; 3920066; -.
DR   KEGG; sao:SAOUHSC_01361; -.
DR   PATRIC; fig|93061.5.peg.1245; -.
DR   eggNOG; COG1316; Bacteria.
DR   HOGENOM; CLU_016455_1_0_9; -.
DR   OMA; IGEQNNH; -.
DR   PRO; PR:Q7BHL7; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004474; LytR_CpsA_psr.
DR   Pfam; PF03816; LytR_cpsA_psr; 1.
DR   TIGRFAMs; TIGR00350; lytR_cpsA_psr; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Signal-anchor; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Regulatory protein MsrR"
FT                   /id="PRO_0000218501"
FT   TOPO_DOM        1..31
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..327
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  36971 MW;  E4D41396379B9070 CRC64;
     MDKETNDNEY RRQSEHRTSA PKRKKKKKIR KLPIILLIVV ILLIALVVYI VHSYNSGVEY
     AKKHAKDVKV HQFNGPVKND GKISILVLGA DKAQGGQSRT DSIMVVQYDF INKKMKMMSV
     MRDIYADIPG YGKHKINSAY ALGGPELLRK TLDKNLGINP EYYAVVDFTG FEKMIDELMP
     EGVPINVEKD MSKNIGVSLK KGNHRLNGKE LLGYARFRHD PEGDFGRVRR QQQVMQTLKK
     EMVNFRTVVK LPKVAGILRG YVNTNIPDSG IFQTGLSFGI RGEKDVKSLT VPIKNSYEDV
     NTNTDGSALQ INKNTNKQAI KDFLDED