ID   MSRR_STAAN              Reviewed;         327 AA.
AC   Q99Q02;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Regulatory protein MsrR;
GN   Name=msrR; OrderedLocusNames=SA1195;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=N315;
RA   Vaezzadeh A.R., Deshusses J., Lescuyer P., Hochstrasser D.F.;
RT   "Shotgun proteomic analysis of total and membrane protein extracts of S.
RT   aureus strain N315.";
RL   Submitted (OCT-2007) to UniProtKB.
CC   -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC       and teicoplanin, as well as the synthesis of virulence factors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BA000018; BAB42454.1; -; Genomic_DNA.
DR   PIR; B89912; B89912.
DR   RefSeq; WP_000356975.1; NC_002745.2.
DR   PDB; 6UEX; X-ray; 1.90 A; A=80-327.
DR   PDBsum; 6UEX; -.
DR   AlphaFoldDB; Q99Q02; -.
DR   SMR; Q99Q02; -.
DR   EnsemblBacteria; BAB42454; BAB42454; BAB42454.
DR   KEGG; sau:SA1195; -.
DR   HOGENOM; CLU_016455_1_0_9; -.
DR   OMA; IGEQNNH; -.
DR   BioCyc; MetaCyc:MON-19995; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004474; LytR_CpsA_psr.
DR   Pfam; PF03816; LytR_cpsA_psr; 1.
DR   TIGRFAMs; TIGR00350; lytR_cpsA_psr; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Membrane; Signal-anchor; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Regulatory protein MsrR"
FT                   /id="PRO_0000218504"
FT   TOPO_DOM        1..31
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..327
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          82..92
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          98..109
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   TURN            110..113
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          114..120
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          124..128
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   TURN            129..131
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          132..135
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   HELIX           138..156
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          161..166
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   HELIX           168..178
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          183..187
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   TURN            193..195
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          201..206
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   HELIX           208..216
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   TURN            219..222
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   HELIX           223..242
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   HELIX           245..248
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   HELIX           251..261
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   HELIX           268..281
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          287..292
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          296..301
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          303..305
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   STRAND          307..311
FT                   /evidence="ECO:0007829|PDB:6UEX"
FT   HELIX           313..325
FT                   /evidence="ECO:0007829|PDB:6UEX"
SQ   SEQUENCE   327 AA;  36971 MW;  E4D41396379B9070 CRC64;
     MDKETNDNEY RRQSEHRTSA PKRKKKKKIR KLPIILLIVV ILLIALVVYI VHSYNSGVEY
     AKKHAKDVKV HQFNGPVKND GKISILVLGA DKAQGGQSRT DSIMVVQYDF INKKMKMMSV
     MRDIYADIPG YGKHKINSAY ALGGPELLRK TLDKNLGINP EYYAVVDFTG FEKMIDELMP
     EGVPINVEKD MSKNIGVSLK KGNHRLNGKE LLGYARFRHD PEGDFGRVRR QQQVMQTLKK
     EMVNFRTVVK LPKVAGILRG YVNTNIPDSG IFQTGLSFGI RGEKDVKSLT VPIKNSYEDV
     NTNTDGSALQ INKNTNKQAI KDFLDED