ID   MSRR_STAAR              Reviewed;         327 AA.
AC   Q6GH43;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Regulatory protein MsrR;
GN   Name=msrR; OrderedLocusNames=SAR1374;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC       and teicoplanin, as well as the synthesis of virulence factors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX571856; CAG40372.1; -; Genomic_DNA.
DR   RefSeq; WP_000356975.1; NC_002952.2.
DR   AlphaFoldDB; Q6GH43; -.
DR   SMR; Q6GH43; -.
DR   KEGG; sar:SAR1374; -.
DR   HOGENOM; CLU_016455_1_0_9; -.
DR   OMA; IGEQNNH; -.
DR   OrthoDB; 491753at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004474; LytR_CpsA_psr.
DR   Pfam; PF03816; LytR_cpsA_psr; 1.
DR   TIGRFAMs; TIGR00350; lytR_cpsA_psr; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Signal-anchor; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Regulatory protein MsrR"
FT                   /id="PRO_0000218505"
FT   TOPO_DOM        1..31
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..327
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  36971 MW;  E4D41396379B9070 CRC64;
     MDKETNDNEY RRQSEHRTSA PKRKKKKKIR KLPIILLIVV ILLIALVVYI VHSYNSGVEY
     AKKHAKDVKV HQFNGPVKND GKISILVLGA DKAQGGQSRT DSIMVVQYDF INKKMKMMSV
     MRDIYADIPG YGKHKINSAY ALGGPELLRK TLDKNLGINP EYYAVVDFTG FEKMIDELMP
     EGVPINVEKD MSKNIGVSLK KGNHRLNGKE LLGYARFRHD PEGDFGRVRR QQQVMQTLKK
     EMVNFRTVVK LPKVAGILRG YVNTNIPDSG IFQTGLSFGI RGEKDVKSLT VPIKNSYEDV
     NTNTDGSALQ INKNTNKQAI KDFLDED