ID   MSRR_STAAW              Reviewed;         327 AA.
AC   Q7A0Y4;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Regulatory protein MsrR;
GN   Name=msrR; OrderedLocusNames=MW1249;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Involved in SarA attenuation. Affects resistance to oxacillin
CC       and teicoplanin, as well as the synthesis of virulence factors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LytR/CpsA/Psr (LCP) family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB95114.1; -; Genomic_DNA.
DR   RefSeq; WP_000356975.1; NC_003923.1.
DR   AlphaFoldDB; Q7A0Y4; -.
DR   SMR; Q7A0Y4; -.
DR   EnsemblBacteria; BAB95114; BAB95114; BAB95114.
DR   KEGG; sam:MW1249; -.
DR   HOGENOM; CLU_016455_1_0_9; -.
DR   OMA; IGEQNNH; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004474; LytR_CpsA_psr.
DR   Pfam; PF03816; LytR_cpsA_psr; 1.
DR   TIGRFAMs; TIGR00350; lytR_cpsA_psr; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Signal-anchor; Transcription;
KW   Transcription regulation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..327
FT                   /note="Regulatory protein MsrR"
FT                   /id="PRO_0000218507"
FT   TOPO_DOM        1..31
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..327
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   327 AA;  36971 MW;  E4D41396379B9070 CRC64;
     MDKETNDNEY RRQSEHRTSA PKRKKKKKIR KLPIILLIVV ILLIALVVYI VHSYNSGVEY
     AKKHAKDVKV HQFNGPVKND GKISILVLGA DKAQGGQSRT DSIMVVQYDF INKKMKMMSV
     MRDIYADIPG YGKHKINSAY ALGGPELLRK TLDKNLGINP EYYAVVDFTG FEKMIDELMP
     EGVPINVEKD MSKNIGVSLK KGNHRLNGKE LLGYARFRHD PEGDFGRVRR QQQVMQTLKK
     EMVNFRTVVK LPKVAGILRG YVNTNIPDSG IFQTGLSFGI RGEKDVKSLT VPIKNSYEDV
     NTNTDGSALQ INKNTNKQAI KDFLDED