ID   MSS11_CANAL             Reviewed;         638 AA.
AC   Q59N20; A0A1D8PSW0; Q59N03;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Transcription activator MSS11;
GN   Name=MSS11; OrderedLocusNames=CAALFM_CR04840CA;
GN   ORFNames=CaO19.13686, CaO19.6309;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH FLO8.
RX   PubMed=19734367; DOI=10.1128/ec.00190-09;
RA   Su C., Li Y., Lu Y., Chen J.;
RT   "Mss11, a transcriptional activator, is required for hyphal development in
RT   Candida albicans.";
RL   Eukaryot. Cell 8:1780-1791(2009).
CC   -!- FUNCTION: Transcription factor that regulates pseudohyphal
CC       differentiation, invasive growth, floculation, adhesion and starch
CC       metabolism in response to nutrient availability.
CC       {ECO:0000269|PubMed:19734367}.
CC   -!- SUBUNIT: Interacts with FLO8. {ECO:0000269|PubMed:19734367}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MSS11 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31217.1; -; Genomic_DNA.
DR   RefSeq; XP_711094.2; XM_706002.2.
DR   AlphaFoldDB; Q59N20; -.
DR   BioGRID; 1230377; 2.
DR   STRING; 237561.Q59N20; -.
DR   PRIDE; Q59N20; -.
DR   GeneID; 3647296; -.
DR   KEGG; cal:CAALFM_CR04840CA; -.
DR   CGD; CAL0000199904; MSS11.
DR   VEuPathDB; FungiDB:CR_04840C_A; -.
DR   eggNOG; ENOG502S549; Eukaryota.
DR   HOGENOM; CLU_027504_0_0_1; -.
DR   InParanoid; Q59N20; -.
DR   OrthoDB; 1639902at2759; -.
DR   PHI-base; PHI:4220; -.
DR   PRO; PR:Q59N20; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031326; P:regulation of cellular biosynthetic process; IEA:UniProt.
DR   InterPro; IPR006594; LisH.
DR   SMART; SM00667; LisH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..638
FT                   /note="Transcription activator MSS11"
FT                   /id="PRO_0000333383"
FT   DOMAIN          29..61
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          270..331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          572..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  72255 MW;  DFE974C892BFEC31 CRC64;
     MSKPPPQHQS KNANNSLSSP VSDKQSNDSR QLLLAHLYNY FKTNGLEETA QALLIECNNT
     IPKATTNSKG YSLDNSGPDQ KDTFLDQWWG LLWSIQSSIN PNLNQMTNPS GILTPQHQMI
     VQQRMLQQQQ QQAQQQQQQA QQQQAQQQQQ QQQLLQQQRL QQQAMIQQQH QQQLINNLSA
     RQQQVGLSTT TNQMGPPGSN SNNLQSNMSP NNEQLQSQAR LQQLKLQFQQ QQQQQLQQQQ
     QQLQLQQQQQ QQQQQQQQQQ QQQQQQQRQQ QRQRQKKFQR QLSTSSQKSP VINNGQPQQQ
     LQQDQRPASA PQNQPTPGNN NNNNNNTNAV SPKLHRQSVD DYQMNLLQME NQNNSQRQKY
     LNNQQTRNSQ QQQQQQQSQS QSQQSSPFQP PAQQPKNSTT TSTNTTTSRA QKSSRKQQPK
     NSRRQSVQQQ QQQQPQQQPQ QSQQMSTSSQ SFTAANNSNN VNNTFDISPQ IQDQGMLSTK
     EQQQQPQQPQ PQPQSQPQSQ SQSLPSNNNN NNNNKQDVVN VVFDDAFFSG NLLLDDFNEF
     ANSTSNNGNG NGNNDMNSQF NNTQTERIMF SMPPNQNQNQ FPSQSGDGGG GGGGSMQPNF
     FEGIELGDGN NSGNGDDDDA PIITTDWLSS MGSGPGYE