MSS2_YEAST
ID MSS2_YEAST Reviewed; 351 AA.
AC P40990; D6VRP3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Protein MSS2, mitochondrial;
DE Flags: Precursor;
GN Name=MSS2; OrderedLocusNames=YDL107W; ORFNames=D2340;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204510 / AB320;
RX PubMed=7857963; DOI=10.1016/0005-2728(94)00198-e;
RA Simon M., Seraphin B., Faye G.;
RT "The nuclear-encoded MSS2 gene is involved in the expression of the
RT mitochondrial cytochrome-c oxidase subunit 2 (Cox2).";
RL Biochim. Biophys. Acta 1228:95-98(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8896274;
RX DOI=10.1002/(sici)1097-0061(199609)12:10b<1077::aid-yea8>3.0.co;2-z;
RA Saiz J.E., Buitrago M.J., Garcia R., Revuelta J.L., del Rey F.;
RT "The sequence of a 20.3 kb DNA fragment from the left arm of Saccharomyces
RT cerevisiae chromosome IV contains the KIN28, MSS2, PHO2, POL3 and DUN1
RT genes, and six new open reading frames.";
RL Yeast 12:1077-1084(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP FUNCTION.
RX PubMed=11604502; DOI=10.1128/mcb.21.22.7663-7672.2001;
RA Broadley S.A., Demlow C.M., Fox T.D.;
RT "Peripheral mitochondrial inner membrane protein, Mss2p, required for
RT export of the mitochondrially coded Cox2p C tail in Saccharomyces
RT cerevisiae.";
RL Mol. Cell. Biol. 21:7663-7672(2001).
RN [6]
RP INTERACTION WITH COX18.
RX PubMed=11950926; DOI=10.1091/mbc.01-12-0580;
RA Saracco S.A., Fox T.D.;
RT "Cox18p is required for export of the mitochondrially encoded Saccharomyces
RT cerevisiae Cox2p C-tail and interacts with Pnt1p and Mss2p in the inner
RT membrane.";
RL Mol. Biol. Cell 13:1122-1131(2002).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Required to stabilize mitochondrial cytochrome C oxidase
CC subunit 2 (COX2) and to translocate the C-terminal domain of COX2
CC through the inner membrane. {ECO:0000269|PubMed:11604502}.
CC -!- SUBUNIT: Interacts with COX18. {ECO:0000269|PubMed:11950926}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X81477; CAA57230.1; -; Genomic_DNA.
DR EMBL; X95644; CAA64905.1; -; Genomic_DNA.
DR EMBL; Z74155; CAA98674.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11753.1; -; Genomic_DNA.
DR PIR; S67649; S67649.
DR RefSeq; NP_010176.1; NM_001180166.1.
DR AlphaFoldDB; P40990; -.
DR SMR; P40990; -.
DR BioGRID; 31955; 152.
DR IntAct; P40990; 1.
DR STRING; 4932.YDL107W; -.
DR iPTMnet; P40990; -.
DR MaxQB; P40990; -.
DR PaxDb; P40990; -.
DR PRIDE; P40990; -.
DR EnsemblFungi; YDL107W_mRNA; YDL107W; YDL107W.
DR GeneID; 851451; -.
DR KEGG; sce:YDL107W; -.
DR SGD; S000002265; MSS2.
DR VEuPathDB; FungiDB:YDL107W; -.
DR eggNOG; ENOG502QU4R; Eukaryota.
DR HOGENOM; CLU_047859_0_0_1; -.
DR InParanoid; P40990; -.
DR OMA; WFKLGME; -.
DR BioCyc; YEAST:G3O-29508-MON; -.
DR PRO; PR:P40990; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P40990; protein.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; IDA:SGD.
DR GO; GO:0005759; C:mitochondrial matrix; IDA:SGD.
DR GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IMP:SGD.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR SUPFAM; SSF48452; SSF48452; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Repeat; TPR repeat; Transit peptide.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..351
FT /note="Protein MSS2, mitochondrial"
FT /id="PRO_0000021773"
FT REPEAT 155..188
FT /note="TPR 1"
FT REPEAT 260..294
FT /note="TPR 2"
FT CONFLICT 286..351
FT /note="TGMEIMDLECFFGFFDCCVKEENFKGARDCLESVKKLGNDKDKKTMINVFLE
FT SRKDSIKLLDKARL -> RVWNMT (in Ref. 1)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 351 AA; 41476 MW; EA6E9BFC68464C67 CRC64;
MQRFVSKFVS TPPVPKKFQE IFPKKRTVNK ILFQLDTRLT YHEMYPIFLQ VSQNTNEENI
PWRKKYPYIR SSDIMQMRNV LITLRTQNKF VHKDLLAMED KLLNIAAELG NNDAISILSF
NVIHEYKKEN VKSSYEKDIE TANEFIKKLY ARNHHLTVKL IGDLFFENKT YDKAEKYYQE
FLKLENSTKL AGEVHGKLGE IQIKQVNGFL KAEKSWLSCI ELLEIERSSR WYFLLARLYM
SSEPMKAKAL LENCASIGFK ECFKTLGFLE LNYFNNYERA KEWFKTGMEI MDLECFFGFF
DCCVKEENFK GARDCLESVK KLGNDKDKKT MINVFLESRK DSIKLLDKAR L
