MSS4_MOUSE
ID MSS4_MOUSE Reviewed; 123 AA.
AC Q91X96; Q3U2X4;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Guanine nucleotide exchange factor MSS4 {ECO:0000305};
DE AltName: Full=Rab-interacting factor;
GN Name=Rabif {ECO:0000312|MGI:MGI:2138605};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Brain, Eye, Inner ear, and Ovary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, and Retina;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Guanine-nucleotide-releasing protein that acts on members of
CC the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1,
CC RAB3A and RAB10, but is less active on these proteins than on the SEC4
CC protein. Might play a general role in vesicular transport (By
CC similarity). {ECO:0000250|UniProtKB:P47224}.
CC -!- SUBUNIT: Interacts with RAB8A. {ECO:0000250|UniProtKB:P47224}.
CC -!- SIMILARITY: Belongs to the DSS4/MSS4 family. {ECO:0000255|PROSITE-
CC ProRule:PRU01132}.
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DR EMBL; AK087547; BAC39922.1; -; mRNA.
DR EMBL; AK133528; BAE21707.1; -; mRNA.
DR EMBL; AK155054; BAE33016.1; -; mRNA.
DR EMBL; AK158129; BAE34373.1; -; mRNA.
DR EMBL; AK165748; BAE38365.1; -; mRNA.
DR EMBL; BC011166; AAH11166.1; -; mRNA.
DR EMBL; BC024808; AAH24808.1; -; mRNA.
DR CCDS; CCDS15310.1; -.
DR RefSeq; NP_663485.1; NM_145510.1.
DR AlphaFoldDB; Q91X96; -.
DR SMR; Q91X96; -.
DR BioGRID; 221108; 1.
DR CORUM; Q91X96; -.
DR IntAct; Q91X96; 1.
DR STRING; 10090.ENSMUSP00000038335; -.
DR PhosphoSitePlus; Q91X96; -.
DR EPD; Q91X96; -.
DR MaxQB; Q91X96; -.
DR PaxDb; Q91X96; -.
DR PeptideAtlas; Q91X96; -.
DR PRIDE; Q91X96; -.
DR ProteomicsDB; 290065; -.
DR Antibodypedia; 34532; 112 antibodies from 26 providers.
DR DNASU; 98710; -.
DR Ensembl; ENSMUST00000047978; ENSMUSP00000038335; ENSMUSG00000042229.
DR GeneID; 98710; -.
DR KEGG; mmu:98710; -.
DR UCSC; uc007csc.1; mouse.
DR CTD; 5877; -.
DR MGI; MGI:2138605; Rabif.
DR VEuPathDB; HostDB:ENSMUSG00000042229; -.
DR eggNOG; KOG4113; Eukaryota.
DR GeneTree; ENSGT00390000016889; -.
DR HOGENOM; CLU_132754_0_0_1; -.
DR InParanoid; Q91X96; -.
DR OMA; WHSLDDK; -.
DR OrthoDB; 1495679at2759; -.
DR PhylomeDB; Q91X96; -.
DR TreeFam; TF314029; -.
DR BioGRID-ORCS; 98710; 13 hits in 76 CRISPR screens.
DR ChiTaRS; Rabif; mouse.
DR PRO; PR:Q91X96; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q91X96; protein.
DR Bgee; ENSMUSG00000042229; Expressed in tail skin and 250 other tissues.
DR Genevisible; Q91X96; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00246; RabGEF; 1.
DR Gene3D; 2.170.150.10; -; 1.
DR InterPro; IPR007515; Mss4.
DR InterPro; IPR011057; Mss4-like_sf.
DR InterPro; IPR011323; Mss4/transl-control_tumour.
DR PANTHER; PTHR13276; PTHR13276; 1.
DR Pfam; PF04421; Mss4; 1.
DR SUPFAM; SSF51316; SSF51316; 1.
DR PROSITE; PS51796; MSS4; 1.
PE 1: Evidence at protein level;
KW Acetylation; Guanine-nucleotide releasing factor; Metal-binding;
KW Protein transport; Reference proteome; Transport; Zinc.
FT CHAIN 1..123
FT /note="Guanine nucleotide exchange factor MSS4"
FT /id="PRO_0000174175"
FT DOMAIN 9..123
FT /note="MSS4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01132"
FT BINDING 23
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01132"
FT BINDING 26
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01132"
FT BINDING 94
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01132"
FT BINDING 97
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01132"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P47224"
SQ SEQUENCE 123 AA; 13915 MW; 73F3AEEC0DBE8B02 CRC64;
MEPCELQNEL VSAEGRNRKA VLCQRCGSRV LQPGTALFSR RQLFLPSMRK KPDLADGSNP
DGDLLQEHWL VNDMFTFENV GFTKDVGNIK FLVCADCEIG PIGWHCLDDK NSFYVALERV
SHE
