MSSP1_ARATH
ID MSSP1_ARATH Reviewed; 734 AA.
AC Q96290; Q9LM67; Q9SYQ3;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2006, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Monosaccharide-sensing protein 1;
DE AltName: Full=Monosaccharide transporter 1;
DE AltName: Full=Sugar transporter MSSP1;
DE AltName: Full=Sugar transporter MT1;
GN Name=MSSP1; Synonyms=MT1; OrderedLocusNames=At1g20840;
GN ORFNames=F2D10.36, F9H16.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Tjaden J., Neuhaus E.;
RT "A new sugar transport protein from Arabidopsis thaliana.";
RL Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-446 AND SER-480, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=cv. Columbia;
RX PubMed=19245862; DOI=10.1016/j.jprot.2009.02.004;
RA Jones A.M.E., MacLean D., Studholme D.J., Serna-Sanz A., Andreasson E.,
RA Rathjen J.P., Peck S.C.;
RT "Phosphoproteomic analysis of nuclei-enriched fractions from Arabidopsis
RT thaliana.";
RL J. Proteomics 72:439-451(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA90628.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; Z50752; CAA90628.1; ALT_FRAME; mRNA.
DR EMBL; AC007369; AAD30608.1; -; Genomic_DNA.
DR EMBL; AC069251; AAF80627.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30030.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60885.1; -; Genomic_DNA.
DR PIR; H86340; H86340.
DR PIR; T51139; T51139.
DR RefSeq; NP_001319055.1; NM_001332471.1.
DR RefSeq; NP_173508.1; NM_101937.6.
DR AlphaFoldDB; Q96290; -.
DR BioGRID; 23915; 3.
DR STRING; 3702.AT1G20840.1; -.
DR TCDB; 2.A.1.1.84; the major facilitator superfamily (mfs).
DR iPTMnet; Q96290; -.
DR PaxDb; Q96290; -.
DR PRIDE; Q96290; -.
DR ProteomicsDB; 238925; -.
DR EnsemblPlants; AT1G20840.1; AT1G20840.1; AT1G20840.
DR EnsemblPlants; AT1G20840.2; AT1G20840.2; AT1G20840.
DR GeneID; 838676; -.
DR Gramene; AT1G20840.1; AT1G20840.1; AT1G20840.
DR Gramene; AT1G20840.2; AT1G20840.2; AT1G20840.
DR KEGG; ath:AT1G20840; -.
DR Araport; AT1G20840; -.
DR TAIR; locus:2030377; AT1G20840.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_015397_1_0_1; -.
DR InParanoid; Q96290; -.
DR OMA; YGTHENQ; -.
DR OrthoDB; 248228at2759; -.
DR PhylomeDB; Q96290; -.
DR PRO; PR:Q96290; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q96290; baseline and differential.
DR Genevisible; Q96290; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0000325; C:plant-type vacuole; HDA:TAIR.
DR GO; GO:0009705; C:plant-type vacuole membrane; IDA:TAIR.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0009624; P:response to nematode; HEP:TAIR.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..734
FT /note="Monosaccharide-sensing protein 1"
FT /id="PRO_0000259882"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 510..530
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 556..576
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 588..608
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 621..641
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 653..673
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 680..700
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 351..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 446
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19245862"
FT MOD_RES 480
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19245862"
FT CONFLICT 256
FT /note="M -> I (in Ref. 1; CAA90628)"
FT /evidence="ECO:0000305"
FT CONFLICT 681
FT /note="G -> E (in Ref. 1; CAA90628)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 734 AA; 79485 MW; 0232FE8BF850259F CRC64;
MKGATLVALA ATIGNFLQGW DNATIAGAMV YINKDLNLPT SVQGLVVAMS LIGATVITTC
SGPISDWLGR RPMLILSSVM YFVCGLIMLW SPNVYVLCFA RLLNGFGAGL AVTLVPVYIS
ETAPPEIRGQ LNTLPQFLGS GGMFLSYCMV FTMSLSDSPS WRAMLGVLSI PSLLYLFLTV
FYLPESPRWL VSKGRMDEAK RVLQQLCGRE DVTDEMALLV EGLDIGGEKT MEDLLVTLED
HEGDDTLETV DEDGQMRLYG THENQSYLAR PVPEQNSSLG LRSRHGSLAN QSMILKDPLV
NLFGSLHEKM PEAGGNTRSG IFPHFGSMFS TTADAPHGKP AHWEKDIESH YNKDNDDYAT
DDGAGDDDDS DNDLRSPLMS RQTTSMDKDM IPHPTSGSTL SMRRHSTLMQ GNGESSMGIG
GGWHMGYRYE NDEYKRYYLK EDGAESRRGS IISIPGGPDG GGSYIHASAL VSRSVLGPKS
VHGSAMVPPE KIAASGPLWS ALLEPGVKRA LVVGVGIQIL QQFSGINGVL YYTPQILERA
GVDILLSSLG LSSISASFLI SGLTTLLMLP AIVVAMRLMD VSGRRSLLLW TIPVLIVSLV
VLVISELIHI SKVVNAALST GCVVLYFCFF VMGYGPIPNI LCSEIFPTRV RGLCIAICAM
VFWIGDIIVT YSLPVLLSSI GLVGVFSIYA AVCVISWIFV YMKVPETKGM PLEVITDYFA
FGAQAQASAP SKDI
