MSSP3_ARATH
ID MSSP3_ARATH Reviewed; 729 AA.
AC Q9SD00;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Monosaccharide-sensing protein 3;
DE AltName: Full=Sugar transporter MSSP3;
GN Name=MSSP3; OrderedLocusNames=At3g51490; ORFNames=F26O13.130;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Stamme C., Tjaden J., Trentmann O., Emmerlich V., Neuhaus E.;
RT "A novel family of plant monosaccharide transporters is involved in a new
RT type of eukaryotic sugar sensing.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9SD00-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AJ532571; CAD58693.1; -; mRNA.
DR EMBL; AL133452; CAB63013.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78798.1; -; Genomic_DNA.
DR PIR; T45780; T45780.
DR RefSeq; NP_190717.1; NM_115008.1. [Q9SD00-1]
DR AlphaFoldDB; Q9SD00; -.
DR STRING; 3702.AT3G51490.2; -.
DR PaxDb; Q9SD00; -.
DR EnsemblPlants; AT3G51490.1; AT3G51490.1; AT3G51490. [Q9SD00-1]
DR GeneID; 824312; -.
DR Gramene; AT3G51490.1; AT3G51490.1; AT3G51490. [Q9SD00-1]
DR KEGG; ath:AT3G51490; -.
DR Araport; AT3G51490; -.
DR eggNOG; KOG0254; Eukaryota.
DR InParanoid; Q9SD00; -.
DR PhylomeDB; Q9SD00; -.
DR PRO; PR:Q9SD00; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SD00; baseline and differential.
DR Genevisible; Q9SD00; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF00083; Sugar_tr; 2.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Phosphoprotein; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..729
FT /note="Monosaccharide-sensing protein 3"
FT /id="PRO_0000259884"
FT TRANSMEM 5..25
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 511..531
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 557..577
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 581..601
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 610..630
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 650..670
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 673..693
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT REGION 337..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 446
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96290"
SQ SEQUENCE 729 AA; 78828 MW; 241A9415DE43FCCC CRC64;
MRSVVLVALA AAIGNMLQGW DNATIAGAVI YIKKEFHLEK EPKIEGLIVA MSLIGATLIT
TFSGPVSDKV GRRSMLILSS VLYFLSSIVM FWSPNVYVLL FARLLDGFGI GLAVTLVPIY
ISETAPSEIR GLLNTFPQFC GSGGMFLSYC LVFGMSLQES PSWRLMLGVL SIPSIAYFVL
AAFFLPESPR WLVSKGRMDE ARQVLQRLRG REDVSGELAL LVEGLGVGKD TSIEEYVIGP
DNEENEGGNE LPRKDQIKLY GPEDGQSWMA KPVKGQSSLA LASRQGSMLP RGGSLMDPLV
TLFGSIHENL PSENMNASSR SMLFPNMGSI LGMMGRQESQ WDPERNNEDS SDQDENLNSP
LLSPQTTEPD DYHQRTVGTM HRRQSSLFMA NVGETATATS IGGGWQLAWK YNDKVGADGK
RVNGGLQRMY IHEETANNNT NNIPFSRRGS LLSFHPEGDG HDQVNGYVQA AALVSQASMM
PGGKGETAML PKEVKDGPGW RELKEPGVKR ALMVGVGLQI LQQFAGINGV MYYTPQILEE
TGVSSLLTNL GISAESASLL ISALTTLLML PCILVSMRSL MLSTIPILIL SLVTLVIGSL
VNLGGSINAL ISTASVTVYL SCFVMGFGAI PNILCSEIFP TSVRGLCITI CALTFWICDI
IVTYTLPVML KSIGIAGVFG IYAIVCAVAW VFVYLKVPET KGMPLEVISE FFSVGAKQQD
AAASFLSDG
