MST12_MAGO7
ID MST12_MAGO7 Reviewed; 715 AA.
AC G4N3L5;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Transcription factor MST12 {ECO:0000303|PubMed:11952120};
GN Name=MST12 {ECO:0000303|PubMed:11952120}; ORFNames=MGG_12958;
OS Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS fungus) (Pyricularia oryzae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX NCBI_TaxID=242507;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX PubMed=15846337; DOI=10.1038/nature03449;
RA Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL Nature 434:980-986(2005).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=11952120; DOI=10.1094/mpmi.2002.15.3.183;
RA Park G., Xue C., Zheng L., Lam S., Xu J.R.;
RT "MST12 regulates infectious growth but not appressorium formation in the
RT rice blast fungus Magnaporthe grisea.";
RL Mol. Plant Microbe Interact. 15:183-192(2002).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=21283781; DOI=10.1371/journal.ppat.1001261;
RA Liu W., Zhou X., Li G., Li L., Kong L., Wang C., Zhang H., Xu J.R.;
RT "Multiple plant surface signals are sensed by different mechanisms in the
RT rice blast fungus for appressorium formation.";
RL PLoS Pathog. 7:e1001261-e1001261(2011).
CC -!- FUNCTION: Transcription factor that may function downstream of PMK1 to
CC regulate genes involved in infectious hyphae growth (PubMed:11952120).
CC Is not essential for vegetative growth, conidiation or appressorium
CC formation (PubMed:11952120). May be involved in the regulation of the
CC expression of the cell surface sensor MSB2 (PubMed:21283781).
CC {ECO:0000269|PubMed:11952120, ECO:0000269|PubMed:21283781}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Impairs pathogenicity on rice and barley leaves
CC but does not affect appressorium formation (PubMed:11952120). However,
CC fails to penetrate onion epidermal cells and to cause spreading lesions
CC (PubMed:11952120). Reduces significantly the expression of the cell
CC surface sensor MSB2 (PubMed:21283781). {ECO:0000269|PubMed:11952120,
CC ECO:0000269|PubMed:21283781}.
CC -!- SIMILARITY: Belongs to the STE12 transcription factor family.
CC {ECO:0000305}.
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DR EMBL; CM001233; EHA52690.1; -; Genomic_DNA.
DR RefSeq; XP_003712497.1; XM_003712449.1.
DR AlphaFoldDB; G4N3L5; -.
DR SMR; G4N3L5; -.
DR STRING; 318829.MGG_12958T0; -.
DR EnsemblFungi; MGG_12958T0; MGG_12958T0; MGG_12958.
DR GeneID; 5048893; -.
DR KEGG; mgr:MGG_12958; -.
DR VEuPathDB; FungiDB:MGG_12958; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_025505_0_0_1; -.
DR InParanoid; G4N3L5; -.
DR OMA; YVSCILW; -.
DR OrthoDB; 444142at2759; -.
DR PHI-base; PHI:2122; -.
DR PHI-base; PHI:2132; -.
DR PHI-base; PHI:2164; -.
DR PHI-base; PHI:2187; -.
DR Proteomes; UP000009058; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR003120; Ste12.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF02200; STE; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00424; STE; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Virulence; Zinc; Zinc-finger.
FT CHAIN 1..715
FT /note="Transcription factor MST12"
FT /id="PRO_0000453100"
FT ZN_FING 564..588
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 594..616
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 214..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 715 AA; 78656 MW; 0CB30583997D2D81 CRC64;
MYSHPHNAGV AAAPQKPETF MLSTEAQQAL PHDAQVALQQ VDNLKYFLIS APVDWQPDQY
IRRFLLPTGE YVSCVLWNNL FHISGTDIVR CLSFRFQAFG RPVKNSKKFE EGIFSDLRNL
KSGTDASLEE PKSPFLDFLY KNNCIRTQKK QKVFYWYSVP HDRLFLDALE RDLKREKMGQ
EATTMAVSEP ALSFQYDSSQ SLYEQLTKAQ QANSSSFNAQ QVSFPPSQST SPVMRAMDSM
PPPPQMMPQP MPQSMAPLAD GLDAMVPYAA MGMAPGMPPQ PAVKREPDFN RVQYNQNGVP
INQGHQRHAS MPAYGLEYSP APSFVSSHYD DYGNRGISFE PLTPPQQAMG MGAEPAYIAN
EETGLYTAIP DHMNGVNGLN GMIQLPPSNL AGPQFTRSYG SNNVYSVIEG SPTYKQRRRR
SSIPPGMSAI AAATAAATAA HRPSDLRRSV SASVGPVAEG DESLDNSPPG LIYSNQPMSM
ANHQREAMEQ MSRHGTPLST VEGSPGMHNV NLEQQQYPMP SEDMTSPMDD RSRPMAQGGP
SVVRRARSAT VMGSEVGPYP QKSHSCPIPT CGRLFKRLEH LKRHVRTHTQ ERPYICPYCS
KAFSRSDNLA QHKRTHDRAD GGEGLILSGE DEEEYSGDDH LGSLEEASPT SEGGYVTSSL
NSAMAHSNTS QHPGSNAVSP NPGPMSHAPT YNSMQTLMQP MQMSQPQPIN AGGMM
