ID   MST12_MAGOR             Reviewed;         715 AA.
AC   Q96UQ9;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Transcription factor MST12 {ECO:0000303|PubMed:11952120};
GN   Name=MST12 {ECO:0000303|PubMed:11952120};
OS   Magnaporthe oryzae (Rice blast fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=318829;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Guyane 11;
RX   PubMed=11952120; DOI=10.1094/mpmi.2002.15.3.183;
RA   Park G., Xue C., Zheng L., Lam S., Xu J.R.;
RT   "MST12 regulates infectious growth but not appressorium formation in the
RT   rice blast fungus Magnaporthe grisea.";
RL   Mol. Plant Microbe Interact. 15:183-192(2002).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21283781; DOI=10.1371/journal.ppat.1001261;
RA   Liu W., Zhou X., Li G., Li L., Kong L., Wang C., Zhang H., Xu J.R.;
RT   "Multiple plant surface signals are sensed by different mechanisms in the
RT   rice blast fungus for appressorium formation.";
RL   PLoS Pathog. 7:e1001261-e1001261(2011).
CC   -!- FUNCTION: Transcription factor that may function downstream of PMK1 to
CC       regulate genes involved in infectious hyphae growth (PubMed:11952120).
CC       Is not essential for vegetative growth, conidiation or appressorium
CC       formation (PubMed:11952120). May be involved in the regulation of the
CC       expression of the cell surface sensor MSB2 (PubMed:21283781).
CC       {ECO:0000269|PubMed:11952120, ECO:0000269|PubMed:21283781}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- DISRUPTION PHENOTYPE: Impairs pathogenicity on rice and barley leaves
CC       but does not affect appressorium formation (PubMed:11952120). However,
CC       fails to penetrate onion epidermal cells and to cause spreading lesions
CC       (PubMed:11952120). Reduces significantly the expression of the cell
CC       surface sensor MSB2 (PubMed:21283781). {ECO:0000269|PubMed:11952120,
CC       ECO:0000269|PubMed:21283781}.
CC   -!- SIMILARITY: Belongs to the STE12 transcription factor family.
CC       {ECO:0000305}.
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DR   EMBL; AF432913; AAL27626.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q96UQ9; -.
DR   SMR; Q96UQ9; -.
DR   OMA; YVSCILW; -.
DR   PHI-base; PHI:268; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR003120; Ste12.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF02200; STE; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00424; STE; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Metal-binding; Nucleus; Repeat; Transcription; Transcription regulation;
KW   Virulence; Zinc; Zinc-finger.
FT   CHAIN           1..715
FT                   /note="Transcription factor MST12"
FT                   /id="PRO_0000453101"
FT   ZN_FING         564..588
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         594..616
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          214..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          518..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          632..691
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..235
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..691
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  78656 MW;  0CB30583997D2D81 CRC64;
     MYSHPHNAGV AAAPQKPETF MLSTEAQQAL PHDAQVALQQ VDNLKYFLIS APVDWQPDQY
     IRRFLLPTGE YVSCVLWNNL FHISGTDIVR CLSFRFQAFG RPVKNSKKFE EGIFSDLRNL
     KSGTDASLEE PKSPFLDFLY KNNCIRTQKK QKVFYWYSVP HDRLFLDALE RDLKREKMGQ
     EATTMAVSEP ALSFQYDSSQ SLYEQLTKAQ QANSSSFNAQ QVSFPPSQST SPVMRAMDSM
     PPPPQMMPQP MPQSMAPLAD GLDAMVPYAA MGMAPGMPPQ PAVKREPDFN RVQYNQNGVP
     INQGHQRHAS MPAYGLEYSP APSFVSSHYD DYGNRGISFE PLTPPQQAMG MGAEPAYIAN
     EETGLYTAIP DHMNGVNGLN GMIQLPPSNL AGPQFTRSYG SNNVYSVIEG SPTYKQRRRR
     SSIPPGMSAI AAATAAATAA HRPSDLRRSV SASVGPVAEG DESLDNSPPG LIYSNQPMSM
     ANHQREAMEQ MSRHGTPLST VEGSPGMHNV NLEQQQYPMP SEDMTSPMDD RSRPMAQGGP
     SVVRRARSAT VMGSEVGPYP QKSHSCPIPT CGRLFKRLEH LKRHVRTHTQ ERPYICPYCS
     KAFSRSDNLA QHKRTHDRAD GGEGLILSGE DEEEYSGDDH LGSLEEASPT SEGGYVTSSL
     NSAMAHSNTS QHPGSNAVSP NPGPMSHAPT YNSMQTLMQP MQMSQPQPIN AGGMM