MST1L_HUMAN
ID MST1L_HUMAN Reviewed; 715 AA.
AC Q2TV78; B7WPB1; Q13209;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Putative macrophage stimulating 1-like protein;
DE AltName: Full=Brain rescue factor 1;
DE Short=BRF-1;
DE AltName: Full=Hepatocyte growth factor-like protein homolog;
DE Flags: Precursor;
GN Name=MST1L; Synonyms=D1F15S1A, MST1P9, MSTP9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RA Heese K.;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 442-715 (ISOFORM 1).
RC TISSUE=Liver;
RX PubMed=10728827; DOI=10.3109/10425179809020903;
RA Degen S.J., McDowell S.A., Waltz S.E., Gould F., Stuart L.A., Carritt B.;
RT "Structure of the human D1F15S1A locus: a chromosome 1 locus with 97
RT percent identity to the chromosome 3 gene coding for hepatocyte growth
RT factor-like protein.";
RL DNA Seq. 8:409-413(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2TV78-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2TV78-2; Sequence=VSP_034980;
CC -!- SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily.
CC {ECO:0000255|PROSITE-ProRule:PRU00274}.
CC -!- CAUTION: Although it belongs to the peptidase S1 family, it lacks
CC essential His, Asp, and Ser residues of the catalytic triad and is
CC therefore predicted to lack peptidase activity. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC35412.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};
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DR EMBL; AY192149; AAP20103.1; -; mRNA.
DR EMBL; AL021920; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U28055; AAC35412.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001258662.1; NM_001271733.1. [Q2TV78-2]
DR AlphaFoldDB; Q2TV78; -.
DR SMR; Q2TV78; -.
DR BioGRID; 116391; 2.
DR IntAct; Q2TV78; 1.
DR MEROPS; S01.933; -.
DR MEROPS; S01.975; -.
DR iPTMnet; Q2TV78; -.
DR PhosphoSitePlus; Q2TV78; -.
DR BioMuta; HGNC:7390; -.
DR DMDM; 205829211; -.
DR jPOST; Q2TV78; -.
DR MassIVE; Q2TV78; -.
DR PaxDb; Q2TV78; -.
DR PeptideAtlas; Q2TV78; -.
DR PRIDE; Q2TV78; -.
DR ProteomicsDB; 61501; -. [Q2TV78-1]
DR ProteomicsDB; 61502; -. [Q2TV78-2]
DR DNASU; 11223; -.
DR GeneID; 11223; -.
DR CTD; 11223; -.
DR GeneCards; MST1L; -.
DR HGNC; HGNC:7390; MST1L.
DR neXtProt; NX_Q2TV78; -.
DR InParanoid; Q2TV78; -.
DR OrthoDB; 164039at2759; -.
DR PhylomeDB; Q2TV78; -.
DR TreeFam; TF329901; -.
DR PathwayCommons; Q2TV78; -.
DR SignaLink; Q2TV78; -.
DR BioGRID-ORCS; 11223; 11 hits in 179 CRISPR screens.
DR ChiTaRS; MST1L; human.
DR GenomeRNAi; 11223; -.
DR Pharos; Q2TV78; Tdark.
DR PRO; PR:Q2TV78; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q2TV78; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046425; P:regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR CDD; cd00108; KR; 2.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; -; 2.
DR Gene3D; 2.40.20.10; -; 4.
DR InterPro; IPR024174; HGF/MST1.
DR InterPro; IPR000001; Kringle.
DR InterPro; IPR013806; Kringle-like.
DR InterPro; IPR018056; Kringle_CS.
DR InterPro; IPR038178; Kringle_sf.
DR InterPro; IPR003609; Pan_app.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR Pfam; PF00051; Kringle; 3.
DR Pfam; PF00024; PAN_1; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PIRSF; PIRSF001152; HGF_MST1; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00130; KR; 4.
DR SMART; SM00473; PAN_AP; 1.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; SSF50494; 1.
DR SUPFAM; SSF57440; SSF57440; 4.
DR PROSITE; PS00021; KRINGLE_1; 2.
DR PROSITE; PS50070; KRINGLE_2; 4.
DR PROSITE; PS50948; PAN; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Hydrolase; Kringle; Protease;
KW Reference proteome; Repeat; Secreted; Serine protease homolog; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..715
FT /note="Putative macrophage stimulating 1-like protein"
FT /id="PRO_0000346153"
FT DOMAIN 21..110
FT /note="PAN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00315"
FT DOMAIN 63..156
FT /note="Kringle 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT DOMAIN 160..238
FT /note="Kringle 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT DOMAIN 252..345
FT /note="Kringle 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT DOMAIN 353..464
FT /note="Kringle 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00121"
FT DOMAIN 488..713
FT /note="Peptidase S1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
FT DISULFID 127..151
FT /evidence="ECO:0000250"
FT DISULFID 161..238
FT /evidence="ECO:0000250"
FT DISULFID 182..221
FT /evidence="ECO:0000250"
FT DISULFID 210..233
FT /evidence="ECO:0000250"
FT DISULFID 253..345
FT /evidence="ECO:0000250"
FT DISULFID 316..339
FT /evidence="ECO:0000250"
FT DISULFID 354..464
FT /evidence="ECO:0000250"
FT DISULFID 375..447
FT /evidence="ECO:0000250"
FT DISULFID 511..527
FT /evidence="ECO:0000250"
FT DISULFID 606..671
FT /evidence="ECO:0000250"
FT DISULFID 636..650
FT /evidence="ECO:0000250"
FT DISULFID 661..689
FT /evidence="ECO:0000250"
FT VAR_SEQ 506..531
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_034980"
FT CONFLICT 690
FT /note="T -> A (in Ref. 1; AAP20103)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 715 AA; 79694 MW; 3CC227716EBC76AB CRC64;
MAPAPVTLLA PGAASSMSCS QPGQRSPSND FQVLRGTELQ HLLHAVVPGP WQEDVADAEE
CAGRCGPLMD CWAFHYNVSS HGCQLLPWTQ HSPHSRLWHS GRCDLFQEKG EWGYMPTLRN
GLEENFCRNP DGDPGGPWCH TTDPAVRFQS CSIKSCRVAA CVWCNGEEYR GAVDRTESGR
ECQRWDLQHP HQHPFEPGKF LDQGLDDNYC RNPDGSERPW CYTTDPQIER EFCDLPRCGS
EAQPRQEATS VSCFRGKGEG YRGTANTTTA AYLASVGTRK SHISTDLRQK NTRASEVGGG
AGVGTCCCGD LRENFCWNLD GSEAPWCFTL RPGTRVGFCY QIRRCTDDVR PQDCYHGAGE
QYRGTVSKTR KGVQCQRWSA ETPHKLQALT LGRHALMSGT RAWKWLRLPC HDFAPAPASV
HIYLRTACTT GGELLPDPDG DSHGPWCYTM DPRTPFDYCA LRRCDQVQFE KCGKRVDRLD
QRRSKLRVAG GHPGNSPWTV SLRNRQGQHF CAGSLVKEQW ILTARQCFSS CHMPLTGYEV
WLGTLFQNPQ HGEPGLQRVP VAKMLCGPSG SQLVLLKLER SVTLNQRVAL ICLPPEWYVV
PPGTKCEIAG WGETKGTGND TVLNVALLNV ISNQECNIKH RGHVRESEMC TEGLLAPVGA
CEGDYGGPLA CFTHNCWVLK GIRIPNRVCT RSRWPAVFTR VSVFVDWIHK VMRLG
