MST4_ORYSJ
ID MST4_ORYSJ Reviewed; 515 AA.
AC Q10PW9; Q6VEF2;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Sugar transport protein MST4 {ECO:0000305};
DE AltName: Full=Monosaccharide transporter 4 {ECO:0000303|PubMed:17874189};
DE Short=OsMST4 {ECO:0000303|PubMed:17874189};
DE AltName: Full=Sugar:proton symporter MST4 {ECO:0000305};
GN Name=MST4 {ECO:0000303|PubMed:17874189};
GN OrderedLocusNames=Os03g0218400 {ECO:0000312|EMBL:BAF11310.1},
GN LOC_Os03g11900 {ECO:0000312|EMBL:ABF94668.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=17874189; DOI=10.1007/s11103-007-9228-x;
RA Wang Y., Xu H., Wei X., Chai C., Xiao Y., Zhang Y., Chen B., Xiao G.,
RA Ouwerkerk P.B., Wang M., Zhu Z.;
RT "Molecular cloning and expression analysis of a monosaccharide transporter
RT gene OsMST4 from rice (Oryza sativa L.).";
RL Plant Mol. Biol. 65:439-451(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [7]
RP FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, AND INDUCTION.
RX PubMed=18506478; DOI=10.1007/s00425-008-0755-8;
RA Wang Y., Xiao Y., Zhang Y., Chai C., Wei G., Wei X., Xu H., Wang M.,
RA Ouwerkerk P.B., Zhu Z.;
RT "Molecular cloning, functional characterization and expression analysis of
RT a novel monosaccharide transporter gene OsMST6 from rice (Oryza sativa
RT L.).";
RL Planta 228:525-535(2008).
CC -!- FUNCTION: Mediates active uptake of hexoses by sugar:proton symport
CC (Probable). Can transport glucose, fructose, mannose and galactose
CC (PubMed:17874189, PubMed:18506478). Can transport xylose and ribose
CC (PubMed:18506478). {ECO:0000269|PubMed:17874189,
CC ECO:0000269|PubMed:18506478, ECO:0000305|PubMed:17874189}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=209.2 uM for glucose {ECO:0000269|PubMed:18506478};
CC KM=271.1 uM for fructose {ECO:0000269|PubMed:18506478};
CC KM=102.4 uM for mannose {ECO:0000269|PubMed:18506478};
CC KM=95 uM for galactose {ECO:0000269|PubMed:18506478};
CC KM=142.4 uM for ribose {ECO:0000269|PubMed:18506478};
CC KM=135.2 uM for xylose {ECO:0000269|PubMed:18506478};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, shoots, leaf blades, leaf
CC sheaths, anthers, ovaries and embryos. {ECO:0000269|PubMed:17874189}.
CC -!- INDUCTION: Induced by glucose, sucrose and salt stress.
CC {ECO:0000269|PubMed:18506478}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AY342321; AAQ24871.1; -; mRNA.
DR EMBL; DP000009; ABF94668.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF11310.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS82992.1; -; Genomic_DNA.
DR EMBL; AK069202; BAG91313.1; -; mRNA.
DR EMBL; AK099306; BAG94054.1; -; mRNA.
DR RefSeq; XP_015630449.1; XM_015774963.1.
DR AlphaFoldDB; Q10PW9; -.
DR SMR; Q10PW9; -.
DR STRING; 4530.OS03T0218400-01; -.
DR PaxDb; Q10PW9; -.
DR PRIDE; Q10PW9; -.
DR EnsemblPlants; Os03t0218400-01; Os03t0218400-01; Os03g0218400.
DR GeneID; 4332079; -.
DR Gramene; Os03t0218400-01; Os03t0218400-01; Os03g0218400.
DR KEGG; osa:4332079; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q10PW9; -.
DR OMA; VMVVFAC; -.
DR OrthoDB; 430696at2759; -.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblPlants.
DR GO; GO:0005358; F:high-affinity glucose:proton symporter activity; IEA:EnsemblPlants.
DR GO; GO:0009737; P:response to abscisic acid; IEA:EnsemblPlants.
DR GO; GO:0009651; P:response to salt stress; IEA:EnsemblPlants.
DR GO; GO:0009414; P:response to water deprivation; IEA:EnsemblPlants.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Sugar transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..515
FT /note="Sugar transport protein MST4"
FT /id="PRO_0000441038"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..78
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 79..99
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..108
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 130..138
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..165
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..199
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 200..220
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..280
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 302..315
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 348..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..379
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 401..422
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 444..448
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 470..515
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CONFLICT 339
FT /note="V -> A (in Ref. 1; AAQ24871)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 515 AA; 56775 MW; 88800D7DAE8B7C72 CRC64;
MAGGFSVSGS GVEFEAKITP IVIISCIMAA TGGLMFGYDV GISGGVTSMD DFLREFFPTV
LKKKHEDKES NYCKYDNQGL QLFTSSLYLA GLTATFFASY TTRRLGRRLT MLIAGVFFIV
GVIFNGAAQN LAMLIVGRIL LGCGVGFANQ AVPLFLSEIA PTRIRGGLNI LFQLNVTIGI
LFANLVNYGT AKIHPWGWRL SLSLAGIPAA LLTLGALFVV DTPNSLIERG RLEEGKAVLR
KIRGTDNVEP EFNEIVEASR VAQEVKHPFR NLLQRRNRPQ LVIAVLLQIF QQFTGINAIM
FYAPVLFNTL GFKTDASLYS AVITGAVNVL STLVSVYSVD RVGRRMLLLE AGVQMFLSQV
AIAVVLGIKV TDRSDNLGHG WAIMVVVMVC TFVSSFAWSW GPLGWLIPSE TFPLETRSAG
QSVTVCVNLL FTFVIAQAFL SMLCHLKYAI FAFFSAWVVV MSLFVLFFLP ETKNIPIEEM
TERVWKQHWF WKRFMDDADK HHVVPNGGKS NGATV
