MST6_ORYSJ
ID MST6_ORYSJ Reviewed; 530 AA.
AC Q6Z401; Q6VEF1;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Sugar transport protein MST6 {ECO:0000305};
DE AltName: Full=Monosaccharide transporter 6 {ECO:0000303|PubMed:18506478};
DE Short=OsMST5 {ECO:0000303|PubMed:18506478};
DE AltName: Full=Sugar:proton symporter MST6 {ECO:0000305};
GN Name=MST6 {ECO:0000303|PubMed:18506478};
GN OrderedLocusNames=Os07g0559700 {ECO:0000312|EMBL:BAF21895.1},
GN LOC_Os07g37320 {ECO:0000305};
GN ORFNames=OsJ_24726 {ECO:0000312|EMBL:EAZ40284.1},
GN P0567H04.25 {ECO:0000312|EMBL:BAC84043.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES,
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=18506478; DOI=10.1007/s00425-008-0755-8;
RA Wang Y., Xiao Y., Zhang Y., Chai C., Wei G., Wei X., Xu H., Wang M.,
RA Ouwerkerk P.B., Zhu Z.;
RT "Molecular cloning, functional characterization and expression analysis of
RT a novel monosaccharide transporter gene OsMST6 from rice (Oryza sativa
RT L.).";
RL Planta 228:525-535(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Mediates active uptake of hexoses by sugar:proton symport
CC (Probable). Can transport glucose, fructose, mannose, galactose, xylose
CC and ribose (PubMed:18506478). {ECO:0000269|PubMed:18506478,
CC ECO:0000305|PubMed:18506478}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=266.1 uM for glucose {ECO:0000269|PubMed:18506478};
CC KM=256.9 uM for fructose {ECO:0000269|PubMed:18506478};
CC KM=108.4 uM for mannose {ECO:0000269|PubMed:18506478};
CC KM=48.7 uM for galactose {ECO:0000269|PubMed:18506478};
CC KM=109.6 uM for ribose {ECO:0000269|PubMed:18506478};
CC KM=151 uM for xylose {ECO:0000269|PubMed:18506478};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18506478};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in leaf blades, leaf sheaths, anthers,
CC ovaries and embryos. Expressed at low levels in roots and shoots.
CC {ECO:0000269|PubMed:18506478}.
CC -!- INDUCTION: Induced by glucose, sucrose and salt stress.
CC {ECO:0000269|PubMed:18506478}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AY342322; AAQ24872.1; -; mRNA.
DR EMBL; AP005195; BAC84043.1; -; Genomic_DNA.
DR EMBL; AP008213; BAF21895.1; -; Genomic_DNA.
DR EMBL; AP014963; BAT02130.1; -; Genomic_DNA.
DR EMBL; CM000144; EAZ40284.1; -; Genomic_DNA.
DR RefSeq; XP_015647567.1; XM_015792081.1.
DR AlphaFoldDB; Q6Z401; -.
DR SMR; Q6Z401; -.
DR STRING; 4530.OS07T0559700-00; -.
DR PaxDb; Q6Z401; -.
DR PRIDE; Q6Z401; -.
DR EnsemblPlants; Os07t0559700-00; Os07t0559700-00; Os07g0559700.
DR GeneID; 4343590; -.
DR Gramene; Os07t0559700-00; Os07t0559700-00; Os07g0559700.
DR KEGG; osa:4343590; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q6Z401; -.
DR OMA; VWILYMS; -.
DR OrthoDB; 430696at2759; -.
DR Proteomes; UP000000763; Chromosome 7.
DR Proteomes; UP000007752; Chromosome 7.
DR Proteomes; UP000059680; Chromosome 7.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..530
FT /note="Sugar transport protein MST6"
FT /id="PRO_0000441040"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..81
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..119
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..142
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..204
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..323
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 360..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..388
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 389..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 410..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..453
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 454..474
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 475..530
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CONFLICT 369
FT /note="S -> G (in Ref. 1; AAQ24872)"
FT /evidence="ECO:0000305"
FT CONFLICT 374
FT /note="K -> E (in Ref. 1; AAQ24872)"
FT /evidence="ECO:0000305"
FT CONFLICT 457
FT /note="Missing (in Ref. 1; AAQ24872)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 530 AA; 57732 MW; 4394A2E78370FAE7 CRC64;
MAGGVVVNNG GGKDYPGKLT MFVLFACIVA ATGGLIFGYD IGISGGVTSM NPFLIKFFPS
VYRKEQAAEK NQSNQYCKFD SPLLTMFTSS LYLAALVASF FASTVTRVAG RKWSMFGGGV
TFLVGAALNG AAKNVLMLIL GRVLLGVGVG FANQSVPLYL SEMAPARLRG MLNIGFQLMI
TIGILCANLI NYGTAKIKGG WGWRVSLALA AVPAAIIAVG ALFLPDTPNS LIDRGHTDAA
KRMLRRVRGT DDIEEEYNDL VAASEESKLV AHPWRNILQR RYRPQLTMAI AIPLFQQLTG
INVIMFYAPV LFKTLGFADD ASLMSAVITG LVNVFATFVS IVTVDRLGRR KLFLQGGTQM
LACQIVVGSL IGAKFGFSGV ADIPKAYAAF VVLFICAYVA GFAWSWGPLG WLVPSEIFPL
EIRSAGQSIN VSVNMLFTFI IAQAFLPMLC RFKFILFFFF GAWVVIMTLF VAFFLPETKN
VPIEEMVLVW KSHWYWGRFI RDEDVHVGAD VEMPAAGNRN GKVDPAKLAN
