ID   MSTAA_DROME             Reviewed;         462 AA.
AC   O46040; O46041; Q9UB82;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 3.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=SET domain-containing protein SmydA-8, isoform A {ECO:0000305};
DE            EC=2.1.1.- {ECO:0000255|PROSITE-ProRule:PRU00190};
GN   Name=SmydA-8 {ECO:0000312|FlyBase:FBgn0053548};
GN   Synonyms=Msta {ECO:0000312|FlyBase:FBgn0053548};
GN   ORFNames=CG33548 {ECO:0000312|FlyBase:FBgn0053548};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000312|EMBL:AAN09072.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Head;
RX   PubMed=10779958;
RA   Alatortsev V.E., Kovalenko T.A., Kalmykova A.I.;
RT   "Local duplication of genes with insertion of a complex microsatellite.";
RL   Mol. Biol. (Mosk.) 34:300-303(2000).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Oregon-R;
RX   PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA   Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA   Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA   Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA   Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA   Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA   Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA   McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA   Glover D.M.;
RT   "From sequence to chromosome: the tip of the X chromosome of D.
RT   melanogaster.";
RL   Science 287:2220-2222(2000).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=O46040-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=P83501-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA15694.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AJ238707; CAB42051.1; -; mRNA.
DR   EMBL; AE014298; AAN09072.1; -; Genomic_DNA.
DR   EMBL; AL009193; CAA15694.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001014717.1; NM_001014717.2. [O46040-1]
DR   RefSeq; NP_001284812.1; NM_001297883.1. [O46040-1]
DR   AlphaFoldDB; O46040; -.
DR   SMR; O46040; -.
DR   BioGRID; 57739; 2.
DR   IntAct; O46040; 19.
DR   STRING; 7227.FBpp0070406; -.
DR   PaxDb; O46040; -.
DR   DNASU; 31200; -.
DR   EnsemblMetazoa; FBtr0070422; FBpp0070406; FBgn0053548. [O46040-1]
DR   EnsemblMetazoa; FBtr0345599; FBpp0311668; FBgn0053548. [O46040-1]
DR   GeneID; 31200; -.
DR   KEGG; dme:Dmel_CG33548; -.
DR   UCSC; CG33548-RA; d. melanogaster. [O46040-1]
DR   CTD; 31200; -.
DR   FlyBase; FBgn0053548; SmydA-8.
DR   VEuPathDB; VectorBase:FBgn0053548; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_024539_2_0_1; -.
DR   InParanoid; O46040; -.
DR   OMA; ECAHFQR; -.
DR   PhylomeDB; O46040; -.
DR   SignaLink; O46040; -.
DR   BioGRID-ORCS; 31200; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 31200; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0053548; Expressed in head capsule and 12 other tissues.
DR   ExpressionAtlas; O46040; baseline and differential.
DR   Genevisible; O46040; DM.
DR   GO; GO:0000785; C:chromatin; ISS:FlyBase.
DR   GO; GO:0042826; F:histone deacetylase binding; ISS:FlyBase.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; ISS:FlyBase.
DR   GO; GO:0034968; P:histone lysine methylation; ISS:FlyBase.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISS:FlyBase.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..462
FT                   /note="SET domain-containing protein SmydA-8, isoform A"
FT                   /id="PRO_0000096607"
FT   DOMAIN          55..287
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   CONFLICT        76
FT                   /note="A -> S (in Ref. 1; CAB42051)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   462 AA;  52157 MW;  04E956E80BC86416 CRC64;
     MSTAAQCPPP RPGGGGGDTT LAALSAHMAP CRDTTPEQLA QLIDVHLGDL RQEQPNWTIS
     SSTVAGRGVF ATRDIAAGEL IFQERALVTG PTARKGQLSS CICCHETLPQ TGFLCRHRCT
     LPVCETCSDS EEHQAECEHF RRWQPKDVDA EQEQVNPMSL RILTAVRVFH LGKEQRHLVD
     AMQANAERAY RREIIQAAQC FRNFPTTDRV FMDQLFRIVG VLNTNAFEAP CRSGGHETLL
     RGLFPLTAIM NHECTPNASH YFENGRLAVV RAARDIPKGG EITTTYTKIL WGNLTRNIFL
     KMTKHFACDC VRCHDNTENG TYLSALFCRE QGCRGLVIPV QTRTLQPDWR CITCENVFPH
     AKMAKYQDFA LNTINNRINS CSVQDMIHFI NELCPRFCPS SNYVLIEAKL NVIWRMTRFD
     HEEYTPEEMG HMDRYREEVL AILHKLGAGE CTLKKLITGE IQ