MSTAB_DROME
ID MSTAB_DROME Reviewed; 448 AA.
AC P83501;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=SET domain-containing protein SmydA-8, isoform B {ECO:0000305};
DE EC=2.1.1.- {ECO:0000255|PROSITE-ProRule:PRU00190};
GN Name=SmydA-8 {ECO:0000312|FlyBase:FBgn0053548};
GN Synonyms=msta {ECO:0000312|FlyBase:FBgn0053548};
GN ORFNames=CG33548 {ECO:0000312|FlyBase:FBgn0053548};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B;
CC IsoId=P83501-1; Sequence=Displayed;
CC Name=A;
CC IsoId=O46040-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014298; AAF45751.3; -; Genomic_DNA.
DR RefSeq; NP_001014718.1; NM_001014718.2. [P83501-1]
DR AlphaFoldDB; P83501; -.
DR SMR; P83501; -.
DR BioGRID; 57739; 2.
DR DIP; DIP-22689N; -.
DR PRIDE; P83501; -.
DR DNASU; 31200; -.
DR EnsemblMetazoa; FBtr0070421; FBpp0070405; FBgn0053548. [P83501-1]
DR GeneID; 31200; -.
DR UCSC; CG33548-RA; d. melanogaster. [P83501-1]
DR CTD; 31200; -.
DR FlyBase; FBgn0053548; SmydA-8.
DR VEuPathDB; VectorBase:FBgn0053548; -.
DR GeneTree; ENSGT00940000167795; -.
DR SignaLink; P83501; -.
DR BioGRID-ORCS; 31200; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31200; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0053548; Expressed in head capsule and 12 other tissues.
DR ExpressionAtlas; P83501; baseline and differential.
DR Genevisible; P83501; DM.
DR GO; GO:0000785; C:chromatin; ISS:FlyBase.
DR GO; GO:0042826; F:histone deacetylase binding; ISS:FlyBase.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; ISS:FlyBase.
DR GO; GO:0034968; P:histone lysine methylation; ISS:FlyBase.
DR GO; GO:0010629; P:negative regulation of gene expression; ISS:FlyBase.
DR Gene3D; 2.170.270.10; -; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SSF82199; 1.
DR PROSITE; PS50280; SET; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..448
FT /note="SET domain-containing protein SmydA-8, isoform B"
FT /id="PRO_0000096608"
FT DOMAIN 42..273
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
SQ SEQUENCE 448 AA; 51113 MW; F33AABD69D71E358 CRC64;
MSTSTPVTEE PRSSSQMTIS ASTQELAELI NIHLGDLRPE EPSWRVADSP ISGRGIFATR
EIAAGEELFR EHTLLVGPTA HRSMNLRTCT LCYRLIPGST DSAALCPAGC GLPVCSECRD
STRHDLECKL FRKWKPLESQ RIEPRALRIL SVVRCFFLDE ASRKLLYAMQ ANMDRYYMQE
VQRAADCFEH FPREQDMLDY FYRTICAFNT NAFESRSNVD GHEVLVRALF PLAGLLNHQC
TPNAAHHFEN GETIVVCATE RIPAGAEITM SYAKLLWSTL ARKIFLGMTK HFICKCVRCQ
DPTENGTYLS ALFCREQGCR GLVIPVQTRT LQPDWRCITC ENVFPHAKMA KYQDFALNTI
NNRINSCSVQ DMIHFINELC PRFCPSSNYV LIEAKLNVIW RMTRFDHEEY TPEEMGHMDR
YREEVLAILH KLGAGECTLK KLITGEIQ
