MSTN1_MOUSE
ID MSTN1_MOUSE Reviewed; 82 AA.
AC Q99JI1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Musculoskeletal embryonic nuclear protein 1;
GN Name=Mustn1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RA Ievolella C., Zara I., Millino C., Faulkner G., Lanfranchi G.;
RT "Full length sequencing of some human and murine muscular transcript
RT (Telethon Italy project B41).";
RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in the development and regeneration of the
CC musculoskeletal system. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MUSTANG family. {ECO:0000305}.
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DR EMBL; AJ277212; CAC34580.1; -; mRNA.
DR EMBL; AK003360; BAC25032.1; -; mRNA.
DR EMBL; AK003945; BAC25061.1; -; mRNA.
DR EMBL; BC116939; AAI16940.1; -; mRNA.
DR EMBL; BC116941; AAI16942.1; -; mRNA.
DR CCDS; CCDS36849.1; -.
DR RefSeq; NP_852055.1; NM_181390.3.
DR AlphaFoldDB; Q99JI1; -.
DR SMR; Q99JI1; -.
DR STRING; 10090.ENSMUSP00000048427; -.
DR iPTMnet; Q99JI1; -.
DR PhosphoSitePlus; Q99JI1; -.
DR MaxQB; Q99JI1; -.
DR PaxDb; Q99JI1; -.
DR PRIDE; Q99JI1; -.
DR ProteomicsDB; 286071; -.
DR DNASU; 66175; -.
DR Ensembl; ENSMUST00000040715; ENSMUSP00000048427; ENSMUSG00000042485.
DR GeneID; 66175; -.
DR KEGG; mmu:66175; -.
DR UCSC; uc007svu.2; mouse.
DR CTD; 389125; -.
DR MGI; MGI:1913425; Mustn1.
DR VEuPathDB; HostDB:ENSMUSG00000042485; -.
DR eggNOG; ENOG502S75P; Eukaryota.
DR GeneTree; ENSGT00940000153920; -.
DR HOGENOM; CLU_193377_0_0_1; -.
DR InParanoid; Q99JI1; -.
DR OMA; YEVMAEC; -.
DR OrthoDB; 1606707at2759; -.
DR PhylomeDB; Q99JI1; -.
DR TreeFam; TF330732; -.
DR BioGRID-ORCS; 66175; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q99JI1; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q99JI1; protein.
DR Bgee; ENSMUSG00000042485; Expressed in tarsal region and 131 other tissues.
DR Genevisible; Q99JI1; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:InterPro.
DR GO; GO:0035988; P:chondrocyte proliferation; IEA:InterPro.
DR GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IDA:MGI.
DR GO; GO:1902732; P:positive regulation of chondrocyte proliferation; IDA:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:MGI.
DR GO; GO:1902730; P:positive regulation of proteoglycan biosynthetic process; IDA:MGI.
DR GO; GO:0042246; P:tissue regeneration; ISO:MGI.
DR GO; GO:0042060; P:wound healing; ISO:MGI.
DR InterPro; IPR031394; MUSTN1.
DR Pfam; PF15682; Mustang; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..82
FT /note="Musculoskeletal embryonic nuclear protein 1"
FT /id="PRO_0000299448"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 50..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 10..18
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 8..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q80XX4"
FT MOD_RES 6
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q80XX4"
SQ SEQUENCE 82 AA; 8941 MW; 11F30DF130D27E36 CRC64;
MSEAGTPEGP IKKKRPPVKE EDLKGARGTL AKNQDIKSKT YQVMRDYEQA GSAAPSVFSR
NRTGTETVFE KPKEGPAKSV FG
