ID   MSTN1_RAT               Reviewed;          82 AA.
AC   Q80XX4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Musculoskeletal embryonic nuclear protein 1;
DE   AltName: Full=Fracture callus protein MUSTANG;
DE   AltName: Full=Musculoskeletal temporally activated novel gene protein;
GN   Name=Mustn1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=14718386; DOI=10.1096/fj.03-0521com;
RA   Lombardo F., Komatsu D., Hadjiargyrou M.;
RT   "Molecular cloning and characterization of Mustang, a novel nuclear protein
RT   expressed during skeletal development and regeneration.";
RL   FASEB J. 18:52-61(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND THR-6, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May be involved in the development and regeneration of the
CC       musculoskeletal system. {ECO:0000269|PubMed:14718386}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14718386}.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in the musculoskeletal
CC       system (skeletal muscle and tendon). Highly expressed during bone
CC       regeneration, especially during the early phases (post fracure days 3
CC       and 5). Expression within the fracture callus is localized in
CC       osteoprogenitor cells of the periosteum, proliferating chondrocytes,
CC       and young active osteoblasts. {ECO:0000269|PubMed:14718386}.
CC   -!- DEVELOPMENTAL STAGE: Abundantly expressed in developing embryos,
CC       especially in mesenchymal condensations of limbs, vertebral
CC       perichondrium and mesenchymal cells of the intervertebral disks.
CC       {ECO:0000269|PubMed:14718386}.
CC   -!- SIMILARITY: Belongs to the MUSTANG family. {ECO:0000305}.
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DR   EMBL; AY254906; AAP12535.1; -; mRNA.
DR   RefSeq; NP_852033.1; NM_181368.3.
DR   AlphaFoldDB; Q80XX4; -.
DR   SMR; Q80XX4; -.
DR   STRING; 10116.ENSRNOP00000023330; -.
DR   iPTMnet; Q80XX4; -.
DR   PhosphoSitePlus; Q80XX4; -.
DR   PaxDb; Q80XX4; -.
DR   Ensembl; ENSRNOT00000023330; ENSRNOP00000023330; ENSRNOG00000017369.
DR   GeneID; 290553; -.
DR   KEGG; rno:290553; -.
DR   UCSC; RGD:727804; rat.
DR   CTD; 389125; -.
DR   RGD; 727804; Mustn1.
DR   eggNOG; ENOG502S75P; Eukaryota.
DR   GeneTree; ENSGT00940000153920; -.
DR   HOGENOM; CLU_193377_0_0_1; -.
DR   InParanoid; Q80XX4; -.
DR   OMA; YEVMAEC; -.
DR   OrthoDB; 1606707at2759; -.
DR   PhylomeDB; Q80XX4; -.
DR   TreeFam; TF330732; -.
DR   PRO; PR:Q80XX4; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000017369; Expressed in quadriceps femoris and 19 other tissues.
DR   ExpressionAtlas; Q80XX4; baseline and differential.
DR   Genevisible; Q80XX4; RN.
DR   GO; GO:0005654; C:nucleoplasm; IDA:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0002062; P:chondrocyte differentiation; IEA:InterPro.
DR   GO; GO:0035988; P:chondrocyte proliferation; IEA:InterPro.
DR   GO; GO:0030326; P:embryonic limb morphogenesis; IEP:RGD.
DR   GO; GO:0032332; P:positive regulation of chondrocyte differentiation; ISO:RGD.
DR   GO; GO:1902732; P:positive regulation of chondrocyte proliferation; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:1902730; P:positive regulation of proteoglycan biosynthetic process; ISO:RGD.
DR   GO; GO:0042246; P:tissue regeneration; IDA:RGD.
DR   GO; GO:0042060; P:wound healing; IDA:RGD.
DR   InterPro; IPR031394; MUSTN1.
DR   Pfam; PF15682; Mustang; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..82
FT                   /note="Musculoskeletal embryonic nuclear protein 1"
FT                   /id="PRO_0000299449"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           10..18
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        8..28
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         6
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   82 AA;  8985 MW;  603609EFD74EAFD7 CRC64;
     MSEAGTPEAP IKKKRPPVKE EDLKGARGSL SKNQEIKSKT YQVMRDYEQA GSAAPSIFSR
     NRTGTETVFE KPKEGPAKSV FG