ID   MSTO1_DANRE             Reviewed;         591 AA.
AC   Q1L908; Q803N4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Protein misato homolog 1;
GN   Name=msto1; ORFNames=si:dkey-263h23.5, zgc:55470;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the regulation of mitochondrial distribution and
CC       morphology. Required for mitochondrial fusion and mitochondrial network
CC       formation. {ECO:0000250|UniProtKB:Q9BUK6}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q9BUK6}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9BUK6}.
CC   -!- SIMILARITY: Belongs to the misato family. {ECO:0000305}.
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DR   EMBL; CR391989; CAK10881.1; -; Genomic_DNA.
DR   EMBL; BC044406; AAH44406.1; -; mRNA.
DR   RefSeq; NP_956181.1; NM_199887.1.
DR   AlphaFoldDB; Q1L908; -.
DR   STRING; 7955.ENSDARP00000029170; -.
DR   PaxDb; Q1L908; -.
DR   Ensembl; ENSDART00000037515; ENSDARP00000029170; ENSDARG00000024381.
DR   GeneID; 334306; -.
DR   KEGG; dre:334306; -.
DR   CTD; 55154; -.
DR   ZFIN; ZDB-GENE-030131-6238; msto1.
DR   eggNOG; KOG2530; Eukaryota.
DR   GeneTree; ENSGT00530000064067; -.
DR   HOGENOM; CLU_022511_0_0_1; -.
DR   InParanoid; Q1L908; -.
DR   OMA; EILTFQF; -.
DR   OrthoDB; 1321917at2759; -.
DR   PhylomeDB; Q1L908; -.
DR   TreeFam; TF323669; -.
DR   PRO; PR:Q1L908; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 19.
DR   Bgee; ENSDARG00000024381; Expressed in gastrula and 24 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0048311; P:mitochondrion distribution; IBA:GO_Central.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR029209; DML1/Misato_tubulin.
DR   InterPro; IPR019605; Misato_II_tubulin-like.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   Pfam; PF10644; Misat_Tub_SegII; 1.
DR   Pfam; PF14881; Tubulin_3; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW   Reference proteome.
FT   CHAIN           1..591
FT                   /note="Protein misato homolog 1"
FT                   /id="PRO_0000304630"
FT   CONFLICT        111
FT                   /note="S -> R (in Ref. 2; AAH44406)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        128
FT                   /note="S -> P (in Ref. 2; AAH44406)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   591 AA;  64924 MW;  EF8A20DFD83CC17D CRC64;
     MSGACREVVT LQLGHYSNFI GTHWWNLQDA GLVYDADVPA GELQSDVLFR EGLTLAGHVT
     YTPRLIAIDL KGSLQTLRKE GSLYDTENEN SAFTWDGQIM THQESPPSKN SFLQELDNLD
     TGGVLAESDF NHLTSSVDNC SVPGASVAVE TINSSLERIQ KSYRLEGSVR VWSDFLRLHL
     HPRTISVINQ YNHDGESERL EVFGQGEALL QGQVLEDLED RLHFFIEECD YLQGFQVLCD
     LTDGFSGLGS KVTEYLQDSY GGRGILTWGV APVNHPDTSS MKDLYHMMNC ALGTLQMANH
     SSLFCPLTLR GGLCRRPPPP TAFPLLNCDP LLWYHSSSVL ALALDALTVS YRMRHCSATM
     WQLSDALTTS GRKVVSAYGS VPFPMMLGGC LPDALDAFSN AVPWRSLSAC PEISDRRFCF
     SQSVTLKGVD EQSLVSRLLP GMEAPSPLHY ERSGEDVLSA YVRSHYPSSP LAVQLVSSGS
     KVTPPFPQIF SPSLSAQGFL QSHSTPASPS CPPVSCLPVL TSLQSSPAVG LQLSELQRAC
     ASLDLRRVAP SFLTHGPEHA EISEYLEQLR NLAHCYRQSH SRSSSEEDDD D