MSTRO_HUMAN
ID MSTRO_HUMAN Reviewed; 248 AA.
AC Q9BYG7; B7Z2I5; B7Z3B2; E9PAT5; E9PBI3; K7EKJ8; Q8N6K5;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Protein maestro;
DE AltName: Full=Male-specific transcription in the developing reproductive organs;
DE AltName: Full=Protein B29;
GN Name=MRO; Synonyms=B29, C18orf3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, TISSUE
RP SPECIFICITY, AND VARIANT ALA-134.
RC TISSUE=Brain;
RX PubMed=11401430; DOI=10.1006/geno.2000.6454;
RA Yanaihara N., Kohno T., Takakura S., Takei K., Otsuka A., Sunaga N.,
RA Takahashi M., Yamazaki M., Tashiro H., Fukuzumi Y., Fujimori Y.,
RA Hagiwara K., Tanaka T., Yokota J.;
RT "Physical and transcriptional map of a 311-kb segment of chromosome 18q21,
RT a candidate lung tumor suppressor locus.";
RL Genomics 72:169-179(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 6), AND VARIANTS
RP SER-39 AND ALA-134.
RC TISSUE=Brain, Cerebellum, and Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-134.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q9BYG7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BYG7-2; Sequence=VSP_045711, VSP_045712;
CC Name=3;
CC IsoId=Q9BYG7-3; Sequence=Not described;
CC Name=4;
CC IsoId=Q9BYG7-4; Sequence=Not described;
CC Name=5;
CC IsoId=Q9BYG7-5; Sequence=VSP_045711;
CC Name=6;
CC IsoId=Q9BYG7-6; Sequence=VSP_045712;
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11401430}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB042647; BAB40981.1; -; mRNA.
DR EMBL; AK294757; BAH11871.1; -; mRNA.
DR EMBL; AK054702; BAB70797.1; -; mRNA.
DR EMBL; AK295666; BAH12148.1; -; mRNA.
DR EMBL; AC015864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC029860; AAH29860.1; -; mRNA.
DR CCDS; CCDS11947.1; -. [Q9BYG7-1]
DR CCDS; CCDS45867.1; -. [Q9BYG7-2]
DR CCDS; CCDS45868.1; -. [Q9BYG7-5]
DR CCDS; CCDS45869.1; -. [Q9BYG7-6]
DR RefSeq; NP_001120646.1; NM_001127174.1. [Q9BYG7-6]
DR RefSeq; NP_001120647.1; NM_001127175.1. [Q9BYG7-2]
DR RefSeq; NP_001120648.1; NM_001127176.1. [Q9BYG7-5]
DR RefSeq; NP_114145.2; NM_031939.3. [Q9BYG7-1]
DR RefSeq; XP_005258422.1; XM_005258365.3.
DR RefSeq; XP_011524528.1; XM_011526226.2. [Q9BYG7-6]
DR RefSeq; XP_016881524.1; XM_017026035.1. [Q9BYG7-1]
DR RefSeq; XP_016881525.1; XM_017026036.1.
DR RefSeq; XP_016881526.1; XM_017026037.1.
DR AlphaFoldDB; Q9BYG7; -.
DR SMR; Q9BYG7; -.
DR BioGRID; 123789; 2.
DR STRING; 9606.ENSP00000397900; -.
DR GlyGen; Q9BYG7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BYG7; -.
DR PhosphoSitePlus; Q9BYG7; -.
DR BioMuta; MRO; -.
DR DMDM; 161789016; -.
DR PaxDb; Q9BYG7; -.
DR PeptideAtlas; Q9BYG7; -.
DR PRIDE; Q9BYG7; -.
DR Antibodypedia; 58882; 35 antibodies from 11 providers.
DR DNASU; 83876; -.
DR Ensembl; ENST00000256425.6; ENSP00000256425.2; ENSG00000134042.14. [Q9BYG7-1]
DR Ensembl; ENST00000398439.8; ENSP00000381465.2; ENSG00000134042.14. [Q9BYG7-1]
DR Ensembl; ENST00000428869.6; ENSP00000409509.2; ENSG00000134042.14. [Q9BYG7-1]
DR Ensembl; ENST00000431965.6; ENSP00000392614.1; ENSG00000134042.14. [Q9BYG7-2]
DR Ensembl; ENST00000436348.6; ENSP00000397900.1; ENSG00000134042.14. [Q9BYG7-5]
DR Ensembl; ENST00000588444.5; ENSP00000465653.1; ENSG00000134042.14. [Q9BYG7-6]
DR GeneID; 83876; -.
DR KEGG; hsa:83876; -.
DR MANE-Select; ENST00000398439.8; ENSP00000381465.2; NM_031939.6; NP_114145.2.
DR UCSC; uc002lew.5; human. [Q9BYG7-1]
DR CTD; 83876; -.
DR DisGeNET; 83876; -.
DR GeneCards; MRO; -.
DR HGNC; HGNC:24121; MRO.
DR HPA; ENSG00000134042; Tissue enhanced (brain, kidney, testis).
DR MIM; 608080; gene.
DR neXtProt; NX_Q9BYG7; -.
DR OpenTargets; ENSG00000134042; -.
DR PharmGKB; PA134932281; -.
DR VEuPathDB; HostDB:ENSG00000134042; -.
DR eggNOG; KOG2032; Eukaryota.
DR GeneTree; ENSGT00940000161642; -.
DR HOGENOM; CLU_099676_0_0_1; -.
DR InParanoid; Q9BYG7; -.
DR OMA; QFLYANK; -.
DR OrthoDB; 31329at2759; -.
DR PhylomeDB; Q9BYG7; -.
DR TreeFam; TF343191; -.
DR PathwayCommons; Q9BYG7; -.
DR BioGRID-ORCS; 83876; 6 hits in 1069 CRISPR screens.
DR ChiTaRS; MRO; human.
DR GenomeRNAi; 83876; -.
DR Pharos; Q9BYG7; Tdark.
DR PRO; PR:Q9BYG7; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q9BYG7; protein.
DR Bgee; ENSG00000134042; Expressed in medial globus pallidus and 153 other tissues.
DR ExpressionAtlas; Q9BYG7; baseline and differential.
DR Genevisible; Q9BYG7; HS.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..248
FT /note="Protein maestro"
FT /id="PRO_0000248197"
FT REPEAT 128..163
FT /note="HEAT"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..33
FT /note="MDQRQRRILGQPLSIPTSQPKQKRTSMISFFSK -> MAWGSKGIQGWENLA
FT ESSHLATTRESSPPESGTGSGSSRGSRLQEPQ (in isoform 2 and isoform
FT 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045711"
FT VAR_SEQ 144..195
FT /note="Missing (in isoform 2 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045712"
FT VARIANT 39
FT /note="R -> S (in dbSNP:rs4940019)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_027261"
FT VARIANT 134
FT /note="T -> A (in dbSNP:rs2849233)"
FT /evidence="ECO:0000269|PubMed:11401430,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_027262"
SQ SEQUENCE 248 AA; 29054 MW; 57E43D6085BFF069 CRC64;
MDQRQRRILG QPLSIPTSQP KQKRTSMISF FSKVSWKLRF QKREPLKNVF FILAERARDP
SAKKRHMAMR NLGTMAYEAP DKVRKYKKIV LDLLVYGLYD PVNLEVIHES MKTLTVVLGK
IQGKGLGSFF IDITLQTRTL LDDENDSLRY SAFVLFGQLA AFAGRKWKKF FTSQVKQTRD
SLLIHLQDRN PQVAKACKTT FQACSPYLKL KEEYSFQSEE DQRNTKLYQQ LSHYHPEILQ
FFYANKIL
