MSTRO_MOUSE
ID MSTRO_MOUSE Reviewed; 248 AA.
AC Q7TNB4; Q9D3T8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Protein maestro;
DE AltName: Full=Male-specific transcription in the developing reproductive organs;
GN Name=Mro;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=129/Sv;
RX PubMed=12889070; DOI=10.1002/dvdy.10342;
RA Smith L., Van Hateren N., Willan J., Romero R., Blanco G., Siggers P.,
RA Walsh J., Banerjee R., Denney P., Ponting C., Greenfield A.;
RT "Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT
RT repeat protein.";
RL Dev. Dyn. 227:600-607(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-248.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12889070}.
CC -!- TISSUE SPECIFICITY: Prominent expression seen in testis, brain, liver
CC and heart. Weakly expressed in the kidney.
CC {ECO:0000269|PubMed:12889070}.
CC -!- DEVELOPMENTAL STAGE: First detected in the developing male gonad before
CC overt testis differentiation. By 12.5 dpc, expression is restricted to
CC the developing testis cords and its expression is not germ cell-
CC dependent. No expression seen in female gonads between 10.5 and 14.5
CC dpc. {ECO:0000269|PubMed:12889070}.
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DR EMBL; AY243876; AAO60057.1; -; mRNA.
DR EMBL; AK017067; BAB30579.2; -; mRNA.
DR RefSeq; NP_001292811.1; NM_001305882.1.
DR RefSeq; NP_082017.2; NM_027741.3.
DR AlphaFoldDB; Q7TNB4; -.
DR SMR; Q7TNB4; -.
DR STRING; 10090.ENSMUSP00000113392; -.
DR iPTMnet; Q7TNB4; -.
DR PhosphoSitePlus; Q7TNB4; -.
DR MaxQB; Q7TNB4; -.
DR PaxDb; Q7TNB4; -.
DR PRIDE; Q7TNB4; -.
DR DNASU; 71263; -.
DR GeneID; 71263; -.
DR KEGG; mmu:71263; -.
DR CTD; 83876; -.
DR MGI; MGI:2152817; Mro.
DR eggNOG; KOG2032; Eukaryota.
DR InParanoid; Q7TNB4; -.
DR OrthoDB; 31329at2759; -.
DR BioGRID-ORCS; 71263; 0 hits in 56 CRISPR screens.
DR PRO; PR:Q7TNB4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q7TNB4; protein.
DR GO; GO:0005730; C:nucleolus; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045206; Maestro_heat-like_prot.
DR PANTHER; PTHR23120; PTHR23120; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..248
FT /note="Protein maestro"
FT /id="PRO_0000248199"
FT REPEAT 128..163
FT /note="HEAT"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 82
FT /note="Missing (in Ref. 2; BAB30579)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="E -> D (in Ref. 2; BAB30579)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 248 AA; 28567 MW; FF375CBEA636A2DC CRC64;
MEQTRKIPNQ PLPTPTSQSK KRRTPLLSFL SKVSWKLRLQ KRELLKNALF VLAERARDPN
AKKRHLAMRG LGALAREAPD KQVRKYKKVM LDLLVRGLYD PVSSEVIHES VKTLTIMLGK
IQGHGLGSFF IDITLQARTL LDDEDDSVRY SAFVLFGQLA SFAGWRWKKF FTQQVNQTQD
SLLGHLQDES PKVAKACKMT VRACVPYLKP RKVPSFQSEE EQKNHRLSRQ LSHCHPEILL
FFYANKIL
