MST_DROME
ID MST_DROME Reviewed; 574 AA.
AC O01939; Q8MSB2;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Protein misato;
GN Name=mst; ORFNames=CG1424;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC STRAIN=Canton-S;
RX PubMed=9144213; DOI=10.1073/pnas.94.10.5189;
RA Miklos G.L., Yamamoto M.-T., Burns R.G., Maleszka R.;
RT "An essential cell division gene of Drosophila, absent from Saccharomyces,
RT encodes an unusual protein with tubulin-like and myosin-like peptide
RT motifs.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:5189-5194(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-574.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Irregular chromosome segregation during mitosis
CC leading to death before the third instar larval stage. Larvae show
CC abnormalities such as absence of imaginal disk tissue, and reduction in
CC brain size. {ECO:0000269|PubMed:9144213}.
CC -!- MISCELLANEOUS: 'Misato' means 'beautiful dawn' in Japanese.
CC -!- SIMILARITY: Belongs to the misato family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM50812.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF017777; AAC28411.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF50817.1; -; Genomic_DNA.
DR EMBL; AY118952; AAM50812.1; ALT_INIT; mRNA.
DR PIR; T08434; T08434.
DR RefSeq; NP_001285518.1; NM_001298589.1.
DR RefSeq; NP_523435.1; NM_078711.5.
DR AlphaFoldDB; O01939; -.
DR BioGRID; 59394; 20.
DR STRING; 7227.FBpp0076907; -.
DR PaxDb; O01939; -.
DR PRIDE; O01939; -.
DR EnsemblMetazoa; FBtr0077211; FBpp0076907; FBgn0020272.
DR EnsemblMetazoa; FBtr0346380; FBpp0312074; FBgn0020272.
DR GeneID; 33119; -.
DR KEGG; dme:Dmel_CG1424; -.
DR UCSC; CG1424-RA; d. melanogaster.
DR CTD; 33119; -.
DR FlyBase; FBgn0020272; mst.
DR VEuPathDB; VectorBase:FBgn0020272; -.
DR eggNOG; KOG2530; Eukaryota.
DR HOGENOM; CLU_022511_1_0_1; -.
DR InParanoid; O01939; -.
DR OMA; EILTFQF; -.
DR OrthoDB; 1321917at2759; -.
DR PhylomeDB; O01939; -.
DR BioGRID-ORCS; 33119; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 33119; -.
DR PRO; PR:O01939; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0020272; Expressed in secondary oocyte and 18 other tissues.
DR ExpressionAtlas; O01939; baseline and differential.
DR Genevisible; O01939; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0048311; P:mitochondrion distribution; IBA:GO_Central.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IMP:FlyBase.
DR GO; GO:0090307; P:mitotic spindle assembly; IMP:FlyBase.
DR Gene3D; 3.40.50.1440; -; 1.
DR InterPro; IPR029209; DML1/Misato_tubulin.
DR InterPro; IPR019605; Misato_II_tubulin-like.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR Pfam; PF10644; Misat_Tub_SegII; 1.
DR Pfam; PF14881; Tubulin_3; 1.
DR SUPFAM; SSF52490; SSF52490; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..574
FT /note="Protein misato"
FT /id="PRO_0000304632"
SQ SEQUENCE 574 AA; 64783 MW; 4750BE59D6B90FBD CRC64;
MDYTREILTF QFGTYANYVG THFWNQQEAN FRYGDESEQV AEEQLPNNDI LYREGRNDLN
RTTYTPRLLS VDLSGTLGHL PVTGELYGNF VQRDEELLPL STGEELEQVR KRAEESGVCS
PEQLEVQEQS KASISEYQRD LLKNAVVPEK NYQLAATANS WVDFLYARYH PRTLNVLPGL
IRDPTAQALG TYSAGTEMWQ EVSFNEEFCD RIRLYVEECD GLQGFHVLFD IDDGFGGLAG
KCLEHLNDEY SRASFALPLH YPRITSYPQA DTRLSHSIRV VNNVLGYHQL SEQALMFTPL
STLETIWRNN NLKSRSLPGL QWETDNLYQT SALLAAFFDT ATLSYRLRQT PESLLRFCEC
VTPAGRKMTA AGLALPFGLR EGQDLIEFLD QSGDHALLTQ LTPGCEPGTS YVVQSVTARG
IPAERLKRPR ELAGDQLRMA AYSCDSISHM LQLYYQCTYH GSVTNAAATP LPLKTQLPFP
YEMFAAGISR DGYRLPEGAE RETGSRVDSA PMLAAVQNST KLGEHLDNVH AQSHRVQLAK
LQAYSNSGLE RDEYDTALDQ LLEFRDLYAD SQYL
