ID   MSUE_PSEAE              Reviewed;         186 AA.
AC   O31038;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=FMN reductase (NADPH);
DE            EC=1.5.1.38;
DE   AltName: Full=FMN reductase;
GN   Name=msuE; Synonyms=slfA; OrderedLocusNames=PA2357;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10049377; DOI=10.1128/jb.181.5.1464-1473.1999;
RA   Kertesz M.A., Schmidt-Larbig K., Wueest T.;
RT   "A novel reduced flavin mononucleotide-dependent methanesulfonate
RT   sulfonatase encoded by the sulfur-regulated msu operon of Pseudomonas
RT   aeruginosa.";
RL   J. Bacteriol. 181:1464-1473(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=FMNH2 + NADP(+) = FMN + 2 H(+) + NADPH; Xref=Rhea:RHEA:21624,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57618, ChEBI:CHEBI:57783,
CC         ChEBI:CHEBI:58210, ChEBI:CHEBI:58349; EC=1.5.1.38;
CC   -!- SIMILARITY: Belongs to the SsuE family. {ECO:0000305}.
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DR   EMBL; AF026067; AAB82563.1; -; Genomic_DNA.
DR   EMBL; AE004091; AAG05745.1; -; Genomic_DNA.
DR   PIR; F83352; F83352.
DR   RefSeq; NP_251047.1; NC_002516.2.
DR   RefSeq; WP_003089470.1; NZ_QZGE01000021.1.
DR   AlphaFoldDB; O31038; -.
DR   SMR; O31038; -.
DR   STRING; 287.DR97_6075; -.
DR   PaxDb; O31038; -.
DR   PRIDE; O31038; -.
DR   DNASU; 882283; -.
DR   EnsemblBacteria; AAG05745; AAG05745; PA2357.
DR   GeneID; 882283; -.
DR   KEGG; pae:PA2357; -.
DR   PATRIC; fig|208964.12.peg.2466; -.
DR   PseudoCAP; PA2357; -.
DR   HOGENOM; CLU_055322_3_3_6; -.
DR   InParanoid; O31038; -.
DR   OMA; FMSHTLP; -.
DR   PhylomeDB; O31038; -.
DR   BioCyc; PAER208964:G1FZ6-2396-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0052873; F:FMN reductase (NADPH) activity; IEA:UniProtKB-EC.
DR   GO; GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:UniProt.
DR   Gene3D; 3.40.50.360; -; 1.
DR   InterPro; IPR029039; Flavoprotein-like_sf.
DR   InterPro; IPR005025; FMN_Rdtase-like.
DR   InterPro; IPR019912; FMN_Rdtase_MsuE-like.
DR   Pfam; PF03358; FMN_red; 1.
DR   SUPFAM; SSF52218; SSF52218; 1.
DR   TIGRFAMs; TIGR03566; FMN_reduc_MsuE; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..186
FT                   /note="FMN reductase (NADPH)"
FT                   /id="PRO_0000160594"
SQ   SEQUENCE   186 AA;  20028 MW;  752453F9A832ED3C CRC64;
     MTSPFKVVAV SGGTYRPSRT LVLTQALIAE LGQSLPIDSR VIELTDIAAP LGATLARNQA
     PAELQAVLDE IESADLLLVA SPVYRGSYPG LLKHLFDLID LNALIDTPVL LAATGGTERH
     ALVLDHQLRP LFSFFQAITL PIGVYASEAD FDNYRIVSEP LKARIRLAAE RAAPLFGGRS
     ELLKIA