ID   MSX1_BOVIN              Reviewed;         303 AA.
AC   O02786;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2013, sequence version 2.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Homeobox protein MSX-1;
DE   AltName: Full=Msh homeobox 1-like protein;
GN   Name=MSX1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tooth;
RX   PubMed=7626784; DOI=10.3109/10425179509030972;
RA   Iimura T., Oida S., Takeda K., Maruoka Y., Shimokawa H., Ibaraki K.,
RA   Sasaki S.;
RT   "Molecular cloning and sequence of bovine Msx-1 homeobox-containing gene
RT   cDNA from a bovine odontoblast library.";
RL   DNA Seq. 5:233-237(1995).
CC   -!- FUNCTION: Acts as a transcriptional repressor. May play a role in limb-
CC       pattern formation. Acts in cranofacial development and specifically in
CC       odontogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- PTM: Sumoylated by PIAS1, desumoylated by SENP1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-7 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA20367.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D30750; BAA20367.1; ALT_INIT; mRNA.
DR   RefSeq; NP_777223.1; NM_174798.2.
DR   AlphaFoldDB; O02786; -.
DR   SMR; O02786; -.
DR   STRING; 9913.ENSBTAP00000014447; -.
DR   PaxDb; O02786; -.
DR   GeneID; 286872; -.
DR   KEGG; bta:286872; -.
DR   CTD; 4487; -.
DR   eggNOG; KOG0492; Eukaryota.
DR   InParanoid; O02786; -.
DR   OrthoDB; 1226077at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..303
FT                   /note="Homeobox protein MSX-1"
FT                   /id="PRO_0000049082"
FT   DNA_BIND        172..231
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          74..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        15
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO)"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        133
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO)"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   303 AA;  31668 MW;  847FA220365E498F CRC64;
     MAPAADMTSL PLGVKVEDPP FGKPAGGGGG QTPSTTAATA AAMGADAEGA KPKVSPSLLP
     FSVEALMADH RKPGAKKSVL AASEGAQAAG GSAKPLGARP GSLAAPDAPS SPRPLGHFSV
     GGLLKLPEDA LVKAESPEKP ERTPWMQNPR FSPPPSRRLS PPACTLRKHK TNRKPRTPFT
     TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM
     AAKPMLPPAT FGLSFPLGGP AAVAAPAGAS LYGASGPFQR AALPVAPVGL YTAHVGYSMY
     HLT