MSX1_CHICK
ID MSX1_CHICK Reviewed; 249 AA.
AC P28361;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-1992, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Homeobox protein MSX-1;
DE AltName: Full=Homeobox protein Hox-7;
DE Short=CHOX-7;
DE AltName: Full=Msh homeobox 1-like protein;
GN Name=MSX1; Synonyms=HOX7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1682191; DOI=10.1016/0012-1606(91)90345-4;
RA Suzuki H., Padanilam B.J., Vitale E., Ramirez F., Solursh M.;
RT "Repeating developmental expression of G-Hox 7, a novel homeobox-containing
RT gene in the chicken.";
RL Dev. Biol. 148:375-388(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 108-249.
RX PubMed=1684333; DOI=10.1101/gad.5.12b.2363;
RA Robert B., Lyons G., Simandl B.K., Kuroiwa A., Buckingham M.;
RT "The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in
RT developing chick limb buds.";
RL Genes Dev. 5:2363-2374(1991).
CC -!- FUNCTION: Probable morphogenetic role.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA48808.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M76985; AAA48808.1; ALT_FRAME; mRNA.
DR EMBL; X61922; CAA43924.1; -; mRNA.
DR PIR; A43904; A43904.
DR AlphaFoldDB; P28361; -.
DR SMR; P28361; -.
DR VEuPathDB; HostDB:geneid_396484; -.
DR InParanoid; P28361; -.
DR PhylomeDB; P28361; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030509; P:BMP signaling pathway; IDA:MGI.
DR GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR GO; GO:0001503; P:ossification; TAS:AgBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..249
FT /note="Homeobox protein MSX-1"
FT /id="PRO_0000049097"
FT DNA_BIND 122..181
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 109..110
FT /note="AE -> LS (in Ref. 2; CAA43924)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 27547 MW; 234984AC96BD0C06 CRC64;
MGGEEESDKP KVSPSPLPFR RWKGSWPTAE RGRQRRSRGF RAPSRRPSQP RRSDDGGTDV
AAPSRRPLPV RRGAGQAARG RAAQSREPRE AGATPWMQSP RFSPPPPRAE PPACTLRKHK
TNRKPRTPFT TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL
QEAELEKLKM AAKPMLPPAA FGISFPLGGP AVAGASLYGA SSPFQRAGLP VAPVGLYTAH
VGYSMYHLT
