ID   MSX1_DAUMA              Reviewed;         297 AA.
AC   Q2VL79;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Homeobox protein MSX-1;
DE   AltName: Full=Msh homeobox 1-like protein;
DE   Flags: Fragment;
GN   Name=MSX1;
OS   Daubentonia madagascariensis (Aye-aye) (Sciurus madagascariensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Strepsirrhini; Chiromyiformes;
OC   Daubentoniidae; Daubentonia.
OX   NCBI_TaxID=31869;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate 6261;
RX   PubMed=16326750; DOI=10.1093/molbev/msj072;
RA   Perry G.H., Verrelli B.C., Stone A.C.;
RT   "Molecular evolution of the primate developmental genes MSX1 and PAX9.";
RL   Mol. Biol. Evol. 23:644-654(2006).
CC   -!- FUNCTION: Acts as a transcriptional repressor. May play a role in limb-
CC       pattern formation. Acts in cranofacial development and specifically in
CC       odontogenesis (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- PTM: Sumoylated by PIAS1, desumoylated by SENP1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR   EMBL; DQ067485; AAZ30472.1; -; Genomic_DNA.
DR   EMBL; DQ067484; AAZ30472.1; JOINED; Genomic_DNA.
DR   AlphaFoldDB; Q2VL79; -.
DR   SMR; Q2VL79; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW   Repressor; Transcription; Transcription regulation; Ubl conjugation.
FT   CHAIN           <1..297
FT                   /note="Homeobox protein MSX-1"
FT                   /id="PRO_0000049085"
FT   DNA_BIND        166..225
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          64..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          129..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        9
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO)"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        127
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO)"
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   297 AA;  31003 MW;  CBFC82D53456AB9E CRC64;
     MTSLPLGVKV EDSAFGKPAG GGEGQAPSAA AATAAAMGAD EEGAKPKVSP SLLPFSVEAL
     MADHRKPGAK ESALAASEGA QAAGGSAQPL GVRPGSLGAP DAPSSPRPLG HFSVGGLLKL
     PEDALVKAES PEKPERTPWM QSPRFSPPPA RRLSPPACTL RKHKTNRKPR TPFTTAQLLA
     LERKFRQKQY LSIAERAEFS SSLSLTETQV KIWFQNRRAK AKRLQEAELE KLKMAAKPML
     PPAAFGLSFP LGGPAAVAAA AGASLYGASG PFQRAALPVA PVGLYTAHVG YSMYHLT