MSX1_SAIBB
ID MSX1_SAIBB Reviewed; 297 AA.
AC Q2VL86;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Homeobox protein MSX-1;
DE AltName: Full=Msh homeobox 1-like protein;
DE Flags: Fragment;
GN Name=MSX1;
OS Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Saimiriinae; Saimiri.
OX NCBI_TaxID=39432;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate 90362;
RX PubMed=16326750; DOI=10.1093/molbev/msj072;
RA Perry G.H., Verrelli B.C., Stone A.C.;
RT "Molecular evolution of the primate developmental genes MSX1 and PAX9.";
RL Mol. Biol. Evol. 23:644-654(2006).
CC -!- FUNCTION: Acts as a transcriptional repressor. May play a role in limb-
CC pattern formation. Acts in cranofacial development and specifically in
CC odontogenesis (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- PTM: Sumoylated by PIAS1, desumoylated by SENP1. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR EMBL; DQ067473; AAZ30467.1; -; Genomic_DNA.
DR EMBL; DQ067472; AAZ30467.1; JOINED; Genomic_DNA.
DR AlphaFoldDB; Q2VL86; -.
DR SMR; Q2VL86; -.
DR STRING; 39432.ENSSBOP00000014051; -.
DR Proteomes; UP000233220; Whole Genome Shotgun Assembly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Isopeptide bond; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Ubl conjugation.
FT CHAIN <1..297
FT /note="Homeobox protein MSX-1"
FT /id="PRO_0000049096"
FT DNA_BIND 166..225
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 9
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO)"
FT /evidence="ECO:0000250"
FT CROSSLNK 127
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO)"
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 297 AA; 31034 MW; C6F5CDAC588B2AB5 CRC64;
MTSLPLGVKV EDSAFGKPAG GGSGQAPSAA AATAAAMGAD EEGAKPKVSP SLLPFSVEAL
MADHRKPGAK ESSLAASESA QAAGGLTQPL GVPPGSLGAP DAPSSPRPLG HFSVGGLLKL
PEDALVKAES PEKPERTPWM QSPRFSPPPA RRLSPPACTL RKHKTNRKPR TPFTTAQLLA
LERKFRQKQY LSIAERAEFS SSLSLTETQV KIWFQNRRAK AKRLQEAELE KLKMAAKPML
PPAAFGLSFP LGSPAAVAAA AGASLYGASG PFQRAALPVA PVGLYTAHVG YSMYHLT
