MSX2_CHICK
ID MSX2_CHICK Reviewed; 259 AA.
AC P28362;
DT 01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Homeobox protein MSX-2;
DE AltName: Full=Homeobox protein Hox-8;
DE Short=CHOX-8;
DE Short=GHox-8;
GN Name=MSX2; Synonyms=HOX8;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1680378; DOI=10.1016/0925-4773(91)90051-7;
RA Coelho C.N., Sumoy L., Rodgers B.J., Davidson D.R., Hill R.E., Upholt W.B.,
RA Kosher R.A.;
RT "Expression of the chicken homeobox-containing gene GHox-8 during embryonic
RT chick limb development.";
RL Mech. Dev. 34:143-154(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1685987; DOI=10.1242/dev.113.2.431;
RA Yokouchi Y., Ohsugi K., Sasaki H., Kuroiwa A.;
RT "Chicken homeobox gene Msx-1: structure, expression in limb buds and effect
RT of retinoic acid.";
RL Development 113:431-444(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 134-259.
RX PubMed=1684333; DOI=10.1101/gad.5.12b.2363;
RA Robert B., Lyons G., Simandl B.K., Kuroiwa A., Buckingham M.;
RT "The apical ectodermal ridge regulates Hox-7 and Hox-8 gene expression in
RT developing chick limb buds.";
RL Genes Dev. 5:2363-2374(1991).
CC -!- FUNCTION: Acts as a transcriptional regulator in bone development.
CC Binds to DNA (By similarity). Morphogenetic role. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR EMBL; S64478; AAB20018.1; -; mRNA.
DR EMBL; X62097; CAA44007.1; -; mRNA.
DR EMBL; X62541; CAA44425.1; -; mRNA.
DR PIR; JS0660; JS0660.
DR RefSeq; NP_989890.1; NM_204559.1.
DR AlphaFoldDB; P28362; -.
DR SMR; P28362; -.
DR STRING; 9031.ENSGALP00000040969; -.
DR PaxDb; P28362; -.
DR Ensembl; ENSGALT00000065242; ENSGALP00000046638; ENSGALG00000038848.
DR GeneID; 395245; -.
DR KEGG; gga:395245; -.
DR CTD; 4488; -.
DR VEuPathDB; HostDB:geneid_395245; -.
DR eggNOG; KOG0492; Eukaryota.
DR GeneTree; ENSGT00940000159824; -.
DR HOGENOM; CLU_072675_0_0_1; -.
DR InParanoid; P28362; -.
DR OMA; MSPTACT; -.
DR OrthoDB; 1226077at2759; -.
DR PhylomeDB; P28362; -.
DR TreeFam; TF350699; -.
DR PRO; PR:P28362; -.
DR Proteomes; UP000000539; Chromosome 13.
DR Bgee; ENSGALG00000038848; Expressed in ovary and 2 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Osteogenesis;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..259
FT /note="Homeobox protein MSX-2"
FT /id="PRO_0000049102"
FT DNA_BIND 134..193
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 47..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 58
FT /note="S -> N (in Ref. 2; CAA44007)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 259 AA; 28235 MW; 375405ED73E59786 CRC64;
MASPSKAKEV FSSDEEGPAA GAEEHHKVKV SSLPFSVEAL MSDKKPPKEL PLAAAGGSAD
GATVGTSRNL LLPGHGSRDA HSPPGALTKT FDTASVKSEN SEDGTSWIQE AGRYSPPPRH
LSPTACTLRK HKTNRKPRTP FTTSQLLALE RKFRQKQYLS IAERAEFSSS LNLTETQVKI
WFQNRRAKAK RLQEAELEKL KMAAKPMLPS GFSLPFPINS PIQAASLYGT SYPFHRPVLP
IPPVGLYATP VGYSMYHLS
