ID   MSX2_COTJA              Reviewed;         259 AA.
AC   P23410;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Homeobox protein MSX-2;
DE   AltName: Full=MSX-1;
DE   AltName: Full=QUOX-7;
GN   Name=MSX2; Synonyms=MSX1, QUOX-7;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1977161; DOI=10.1073/pnas.87.19.7482;
RA   Takahashi Y., le Douarin N.M.;
RT   "cDNA cloning of a quail homeobox gene and its expression in neural crest-
RT   derived mesenchyme and lateral plate mesoderm.";
RL   Proc. Natl. Acad. Sci. U.S.A. 87:7482-7486(1990).
CC   -!- FUNCTION: Acts as a transcriptional regulator in bone development.
CC       Probable morphogenetic role. Binds to DNA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed in neural crest-derived mesenchyme and
CC       lateral plate mesoderm.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR   EMBL; M57611; AAA63459.1; -; mRNA.
DR   PIR; A38284; A38284.
DR   AlphaFoldDB; P23410; -.
DR   SMR; P23410; -.
DR   Proteomes; UP000694412; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Osteogenesis;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..259
FT                   /note="Homeobox protein MSX-2"
FT                   /id="PRO_0000049103"
FT   DNA_BIND        134..193
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          47..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   259 AA;  28243 MW;  0CDF2512FDCC9A79 CRC64;
     MASPSKAKEV FSSDEEGPAA GAEEHHKVKV SSLPFSVEAL MSDKKPPKEL PLAAAGSSAD
     GATVGTSRNM LLPGHGSRDA HSPPGALTKT FDTASVKSEN SEDGTSWIQE AGRYSPPPRH
     LSPTACTLRK HKTNRKPRTP FTTSQLLALE RKFRQKQYLS IAERAEFSSS LNLTETQVKI
     WFQNRRAKAK RLQEAELEKL KMAANAMLPS GFSLPFPINS PIQAASLYGT SYPFHRPVLP
     IPPVGLYATP VGYSMYHLS