ID   MSX2_PANTR              Reviewed;         267 AA.
AC   A2T764;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   29-SEP-2021, entry version 72.
DE   RecName: Full=Homeobox protein MSX-2;
GN   Name=MSX2;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a transcriptional regulator in bone development.
CC       Represses the ALPL promoter activity and antagonizes the stimulatory
CC       effect of DLX5 on ALPL expression during osteoblast differentiation.
CC       Probable morphogenetic role. May play a role in limb-pattern formation.
CC       In osteoblasts, suppresses transcription driven by the osteocalcin FGF
CC       response element (OCFRE). Binds to the homeodomain-response element of
CC       the ALPL promoter (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR   EMBL; DQ977381; ABM92019.1; -; Genomic_DNA.
DR   STRING; 9598.ENSPTRP00000029971; -.
DR   PaxDb; A2T764; -.
DR   eggNOG; KOG0492; Eukaryota.
DR   InParanoid; A2T764; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR   GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Osteogenesis;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..267
FT                   /note="Homeobox protein MSX-2"
FT                   /id="PRO_0000285451"
FT   DNA_BIND        142..201
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   267 AA;  28921 MW;  7C29BB5F4A7446FB CRC64;
     MASPSKGNDL FSPDEEGPAV VAGPGPGPGG AEGAAEERRV KVSSLPFSVE ALMSDKKPPK
     EASPLPAESA SAGATLRPLL LSGHGAREAH SPGPLVKPFE TASVKSENSE DGAAWMQEPG
     RYSPPPRHMS PTTCTLRKHK TNRKPRXXFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN
     LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSSF SLPFPISSPL QAASIYGASY
     PFHRPVLPIP PVGLYATPVG YGMYHLS