MSX2_RAT
ID MSX2_RAT Reviewed; 139 AA.
AC P52953;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Homeobox protein MSX-2;
DE AltName: Full=Homeobox protein Hox-8-1;
DE Flags: Fragment;
GN Name=Msx2; Synonyms=Msx-2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC TISSUE=Bone;
RX PubMed=7877617; DOI=10.1210/mend.8.11.7877617;
RA Towler D.A., Rutledge S., Rodan G.A.;
RT "Msx-2/Hox 8.1: a transcriptional regulator of the rat osteocalcin
RT promoter.";
RL Mol. Endocrinol. 8:1484-1493(1994).
CC -!- FUNCTION: Acts as a transcriptional regulator in bone development.
CC Represses the ALPL promoter activity and antagonizes the stimulatory
CC effect of DLX5 on ALPL expression during osteoblast differentiation.
CC Probable morphogenetic role. May play a role in limb-pattern formation.
CC In osteoblasts, suppresses transcription driven by the osteocalcin FGF
CC response element (OCFRE). Binds to the homeodomain-response element of
CC the ALPL promoter (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with MINT, with XRCC6 (Ku70) and XRCC5 (Ku80).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR EMBL; U12514; AAA20669.1; -; Genomic_RNA.
DR AlphaFoldDB; P52953; -.
DR SMR; P52953; -.
DR CORUM; P52953; -.
DR STRING; 10116.ENSRNOP00000024765; -.
DR PaxDb; P52953; -.
DR RGD; 3116; Msx2.
DR eggNOG; KOG0492; Eukaryota.
DR InParanoid; P52953; -.
DR PhylomeDB; P52953; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:RGD.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:RGD.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0090427; P:activation of meiosis; ISO:RGD.
DR GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
DR GO; GO:0030509; P:BMP signaling pathway; ISO:RGD.
DR GO; GO:0061312; P:BMP signaling pathway involved in heart development; ISO:RGD.
DR GO; GO:0060349; P:bone morphogenesis; ISO:RGD.
DR GO; GO:0060346; P:bone trabecula formation; ISO:RGD.
DR GO; GO:0060444; P:branching involved in mammary gland duct morphogenesis; ISO:RGD.
DR GO; GO:0051216; P:cartilage development; IMP:RGD.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; ISO:RGD.
DR GO; GO:0071363; P:cellular response to growth factor stimulus; ISO:RGD.
DR GO; GO:0002063; P:chondrocyte development; ISO:RGD.
DR GO; GO:0042733; P:embryonic digit morphogenesis; ISO:RGD.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISO:RGD.
DR GO; GO:0035116; P:embryonic hindlimb morphogenesis; ISO:RGD.
DR GO; GO:0030326; P:embryonic limb morphogenesis; ISO:RGD.
DR GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR GO; GO:0035880; P:embryonic nail plate morphogenesis; ISO:RGD.
DR GO; GO:0070166; P:enamel mineralization; ISO:RGD.
DR GO; GO:0003416; P:endochondral bone growth; ISO:RGD.
DR GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
DR GO; GO:0060364; P:frontal suture morphogenesis; ISO:RGD.
DR GO; GO:0061180; P:mammary gland epithelium development; ISO:RGD.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0032792; P:negative regulation of CREB transcription factor activity; ISO:RGD.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; ISO:RGD.
DR GO; GO:0045617; P:negative regulation of keratinocyte differentiation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0042476; P:odontogenesis; ISO:RGD.
DR GO; GO:0001503; P:ossification; ISO:RGD.
DR GO; GO:0002076; P:osteoblast development; IEP:RGD.
DR GO; GO:0001649; P:osteoblast differentiation; ISS:UniProtKB.
DR GO; GO:0003151; P:outflow tract morphogenesis; ISO:RGD.
DR GO; GO:0003148; P:outflow tract septum morphogenesis; ISO:RGD.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISO:RGD.
DR GO; GO:0010942; P:positive regulation of cell death; IMP:RGD.
DR GO; GO:2001055; P:positive regulation of mesenchymal cell apoptotic process; ISO:RGD.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISO:RGD.
DR GO; GO:0051795; P:positive regulation of timing of catagen; ISO:RGD.
DR GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0023019; P:signal transduction involved in regulation of gene expression; ISO:RGD.
DR GO; GO:0048863; P:stem cell differentiation; ISO:RGD.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IDA:RGD.
DR GO; GO:0042060; P:wound healing; ISO:RGD.
DR GO; GO:0035313; P:wound healing, spreading of epidermal cells; ISO:RGD.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Osteogenesis;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN <1..139
FT /note="Homeobox protein MSX-2"
FT /id="PRO_0000049101"
FT DNA_BIND 14..73
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
SQ SEQUENCE 139 AA; 15839 MW; 819920A2ACD300AD CRC64;
MSPTTCTLRK HKTNRKPRTP FTTSQLLALE RKFRQKQYLS IAERAEFSSS LNLTETQVKI
WFQNRRAKAK RLQEAELEKL KMAAKPMLPS GFSLPFPINS PLQAASIYSA SYPFHRPVLP
IPPVGLYATP VGYGMYHLS
