ID   MSXA_DANRE              Reviewed;         257 AA.
AC   Q03357;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Homeobox protein MSH-A;
GN   Name=msxa; Synonyms=msh-a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=7768177; DOI=10.1242/dev.121.2.347;
RA   Akimenko M.-A., Johnson S.L., Westerfield M., Ekker M.;
RT   "Differential induction of four msx homeobox genes during fin development
RT   and regeneration in zebrafish.";
RL   Development 121:347-357(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 121-181.
RX   PubMed=1673109; DOI=10.1016/0378-1119(91)90182-b;
RA   Holland P.W.H.;
RT   "Cloning and evolutionary analysis of msh-like homeobox genes from mouse,
RT   zebrafish and ascidian.";
RL   Gene 98:253-257(1991).
CC   -!- FUNCTION: Probable morphogenetic role.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR   EMBL; U16310; AAA99705.1; -; mRNA.
DR   EMBL; M38578; AAA50031.1; -; Genomic_DNA.
DR   PIR; PS0408; PS0408.
DR   AlphaFoldDB; Q03357; -.
DR   SMR; Q03357; -.
DR   STRING; 7955.ENSDARP00000073690; -.
DR   PaxDb; Q03357; -.
DR   ZFIN; ZDB-GENE-980526-322; msx2a.
DR   eggNOG; KOG0492; Eukaryota.
DR   InParanoid; Q03357; -.
DR   PRO; PR:Q03357; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048598; P:embryonic morphogenesis; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..257
FT                   /note="Homeobox protein MSH-A"
FT                   /id="PRO_0000049066"
FT   DNA_BIND        122..181
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          18..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..116
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  29117 MW;  01DE43D38CBD2539 CRC64;
     MVLTQNVDTF SGMISANHKS KVSSDEDDDD HGSRSVRTQS LPFSVDALMS TKERSESTSQ
     GSIHMTRIIN QDDRSIYSDS VDFIKRRESA KEDSAWINKP RLSTSPRSQS PTICPLRKHK
     TNRKPRTPFT TAQLLALERK FRQKQYLSIA ERAEFSSSLS LTETQVKIWF QNRRAKAKRL
     QEAELERFKM ASKPILHPGL TLPFPLCTQP QTAALVCGQS FPFSRHMLPF APIGIYSTPM
     GYSMCHLSKD GYSVEPV